Safety of the Transcranial Focal Electrical Stimulation via Tripolar Concentric Ring Electrodes for Hippocampal CA3 Subregion Neurons in Rats.
Safety of the Transcranial Focal Electrical Stimulation via Tripolar Concentric Ring Electrodes for Hippocampal CA3 Subregion Neurons in Rats.
复制标题
通过Tripall同心环电刺激经颅局灶性电刺激的安全性，用于大鼠海马CA3次区域神经元。
DOI：
10.1155/2017/4302810
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发表时间：
2017
影响因子：
--
通讯作者：
Makeyev O
中科院分区：
文献类型：
--
作者：
Mucio-Ramírez S;Makeyev O
癫痫是一种神经系统疾病，影响世界人口的约百分之一。通过三极同心环电极的非侵入性脑电刺激已被提出作为癫痫控制的替代/补充疗法。先前的研究结果表明，它的效力衰减急性癫痫发作青霉素，毛果芸香碱诱导的癫痫持续状态，戊四氮诱导的大鼠癫痫发作模型和其安全性的大鼠头皮，皮质完整性，和记忆形成。在本研究中，神经元计数用于评估大鼠（n = 36）中由于在最后一次刺激剂量后24小时、1周和1个月对海马CA 3亚区神经元进行单次剂量或5次剂量（每24小时给予一次）刺激而可能造成的组织损伤。全析因方差分析显示，对照组和刺激组动物之间的神经元数量无统计学显著差异（p = 0.71）。此外，由于刺激剂量的数量（p = 0.71）和末次刺激剂量后的延迟（p = 0.96），未显示统计学显著差异。获得的结果表明，在电流参数（50 mA，200 μs，300 Hz，双相，电荷平衡脉冲2分钟）下的刺激不会诱导大脑海马CA 3亚区的神经元损伤。
Epilepsy is a neurological disorder that affects approximately one percent of the world population. Noninvasive electrical brain stimulation via tripolar concentric ring electrodes has been proposed as an alternative/complementary therapy for seizure control. Previous results suggest its efficacy attenuating acute seizures in penicillin, pilocarpine-induced status epilepticus, and pentylenetetrazole-induced rat seizure models and its safety for the rat scalp, cortical integrity, and memory formation. In this study, neuronal counting was used to assess possible tissue damage in rats (n = 36) due to the single dose or five doses (given every 24 hours) of stimulation on hippocampal CA3 subregion neurons 24 hours, one week, and one month after the last stimulation dose. Full factorial analysis of variance showed no statistically significant difference in the number of neurons between control and stimulation-treated animals (p = 0.71). Moreover, it showed no statistically significant differences due to the number of stimulation doses (p = 0.71) nor due to the delay after the last stimulation dose (p = 0.96). Obtained results suggest that stimulation at current parameters (50 mA, 200 μs, 300 Hz, biphasic, charge-balanced pulses for 2 minutes) does not induce neuronal damage in the hippocampal CA3 subregion of the brain.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
8
作者：
Besio, Walter G.;Liu, Xiang;Koka, Kanthaiah
通讯作者：
Koka, Kanthaiah
DOI：
10.1109/tnsre.2012.2197865
发表时间：
2012-07-01
影响因子：
4.9
作者：
Makeyev, Oleksandr;Liu, Xiang;Besio, Walter G.
通讯作者：
Besio, Walter G.
影响因子：
3.8
作者：
Besio, W.;Sharma, V.;Spaulding, J.
通讯作者：
Spaulding, J.
生酮饮食可预防癫痫发生以及杏仁核引发癫痫发作时的神经元损失
影响因子：
2.5
作者：
Jiang, Yan;Yang, Yi;Ding, Mei-Ping
通讯作者：
Ding, Mei-Ping