Biomimetic remineralization of dentin.
Biomimetic remineralization of dentin.
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DOI：
10.1016/j.dental.2013.07.013
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发表时间：
2014-01
期刊：
影响因子：
5
通讯作者：
Tay, Franklin R.
中科院分区：
文献类型：
--
作者：
Niu, Li-na;Zhang, Wei;Pashley, David H.;Breschi, Lorenzo;Mao, Jing;Chen, Ji-hua;Tay, Franklin R.
脱矿牙本质的再矿化对提高牙本质粘结稳定性、控制原发龋和继发龋具有重要意义。然而，传统的牙本质再矿化策略不适合于再矿化由蚀刻-冲洗和适度侵蚀性自蚀刻粘合剂系统产生的混合层内的完全脱矿牙本质，或微创龋齿去除后留下的受龋齿影响的牙本质病变的浅表部分。仿生再矿化代表了解决这个问题的一种不同方法，它试图用类似液体的无定形磷酸钙纳米前体颗粒回填脱矿牙本质胶原，这些颗粒由非胶原蛋白的仿生类似物稳定。本文综述了近年来纤维胶原磷酸钙矿化概念的变化，包括最近发现的非经典的基于颗粒的结晶概念、聚合物诱导的液体前体（PILP）的形成、胶原矿化的实验模型以及使用含磷酸盐的仿生类似物进行胶原仿生矿化的必要性。然后回顾了不同研究小组发表的关于树脂牙本质粘结和人工龋样病变再矿化的工作。最后，一个科学合理的概念转化为临床适用的方法相关的问题和进展进行了讨论。基于PILP过程的基于颗粒的仿生再矿化策略在再矿化有缺陷的混合层或龋样牙本质方面表现出巨大的潜力。基于这一概念，研究开发临床上更可行的牙本质再矿化策略，例如在牙本质粘合剂中加入聚（阴离子）酸稳定的无定形磷酸钙纳米前体含介孔二氧化硅纳米填料，可能为增加树脂-牙本质粘合的耐久性和再矿化受龋影响的牙本质提供有前途的策略。
Remineralization of demineralized dentin is important for improving dentin bonding stability and controlling primary and secondary caries. Nevertheless, conventional dentin remineralization strategy is not suitable for remineralizing completely-demineralized dentin within hybrid layers created by etch-and-rinse and moderately aggressive self-etch adhesive systems, or the superficial part of a caries-affected dentin lesion left behind after minimally invasive caries removal. Biomimetic remineralization represents a different approach to this problem by attempting to backfill the demineralized dentin collagen with liquid-like amorphous calcium phosphate nanoprecursor particles that are stabilized by biomimetic analogs of noncollagenous proteins. This paper reviewed the changing concepts in calcium phosphate mineralization of fibrillar collagen, including the recently discovered, non-classical particle-based crystallization concept, formation of polymer-induced liquid- precursors (PILP), experimental collagen models for mineralization, and the need for using phosphate-containing biomimetic analogs for biomimetic mineralization of collagen. Published work on the remineralization of resin-dentin bonds and artificial caries-like lesions by various research groups was then reviewed. Finally, the problems and progress associated with the translation of a scientifically-sound concept into a clinically-applicable approach are discussed. The particle-based biomimetic remineralization strategy based on the PILP process demonstrates great potential in remineralizing faulty hybrid layers or caries-like dentin. Based on this concept, research in the development of more clinically feasible dentin remineralization strategy, such as incorporating poly(anionic) acid-stabilized amorphous calcium phosphate nanoprecursor-containing mesoporous silica nanofillers in dentin adhesives, may provide a promising strategy for increasing of the durability of resin-dentin bonding and remineralizing caries-affected dentin.
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影响因子：
9.7
作者：
Bertassoni LE;Orgel JP;Antipova O;Swain MV
通讯作者：
Swain MV
影响因子：
4.8
作者：
Cross, KJ;Huq, NL;Reynolds, EC
通讯作者：
Reynolds, EC
键的耐用性和粘合剂修复的临床成功。
影响因子：
5
作者：
Carvalho, Ricardo M.;Manso, Adriana P.;Geraldeli, Saulo;Tay, Franklin R.;Pashley, David H.
通讯作者：
Pashley, David H.
影响因子：
3
作者：
Beniash, Elia;Metzler, Rebecca A.;Lam, Raymond S. K.;Gilbert, P. U. P. A.
通讯作者：
Gilbert, P. U. P. A.
影响因子：
--
作者：
Cochrane, N J;Reynolds, E C
通讯作者：
Reynolds, E C