White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with medication, neuropsychological function, and prodromal symptoms of psychosis.
White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with medication, neuropsychological function, and prodromal symptoms of psychosis.
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DOI：
10.1016/j.schres.2014.07.010
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发表时间：
2015-01
影响因子：
4.5
通讯作者：
Coman, Ioana L.
中科院分区：
文献类型：
--
作者：
Kates, Wendy R.;Olszewski, Amy K.;Gnirke, MatthewH.;Kikinis, Zora;Nelson, Joshua;Antshel, Kevin M.;Fremont, Wanda;Radoeva, Petya D.;Middleton, Frank A.;Shenton, Martha E.;Coman, Ioana L.
关键词：
22q11.2缺失综合征(22q11.2DS)被认为是理解神经解剖破坏与精神分裂症高危相关的病因同质性模型。本研究利用弥散张量成像(DTI)对22q11.2DS患者的脑白质微结构进行了分析。我们专注于扣带束(CB)，以前发现精神分裂症患者的扣带束(CB)被破坏，并与精神病症状有关。使用DTIStudio中的纤维束成像算法评估前侧、上侧和后侧CB的白质微结构。对所有参与者的神经心理功能、精神病前驱症状的存在和服药史进行了评估。与对照组相比，患有22q11.2DS的年轻人的CB的大部分DTI指标都发生了变化。改变与阳性的精神病前驱症状有关。然而，当22q11.2DS的个体按抗精神病药物/情绪稳定剂的使用进行划分时，药物组和非药物组在前CB的轴向扩散率和上CB的各向异性分数方面存在显著差异。用药组和对照组之间的DTI指标没有差异。结果表明，22q11.2DS患者CB的微结构发生了改变，这些改变可能是精神病阳性前驱症状的基础。我们的发现进一步提供了初步证据，即抗精神病药物/情绪稳定剂的使用可能对前驱22q11.2DS患者的脑白质微结构具有修复作用，与精神病的潜在影响无关。未来对22q11.2DS患者脑白质病理学的研究应该测试药物对脑白质微结构的潜在影响。
The 22q11.2 Deletion Syndrome (22q11.2DS) is regarded as an etiologically homogenous model for understanding neuroanatomic disruptions associated with a high risk for schizophrenia. This study utilized diffusion tensor imaging (DTI) to analyze white matter microstructure in individuals with 22q11.2DS. We focused on the cingulum bundle (CB), previously shown to be disrupted in patients with schizophrenia and associated with symptoms of psychosis. White matter microstructure was assessed in the anterior, superior, and posterior CB using the tractography algorithm in DTIStudio. Neuropsychological function, presence of prodromal symptoms of psychosis, and medication history were assessed in all participants. Relative to controls, young adults with 22q11.2DS showed alterations in most DTI metrics of the CB. Alterations were associated with positive prodromal symptoms of psychosis. However, when individuals with 22q11.2DS were divided by usage of antipsychotics / mood stabilizers, the medicated and non-medicated groups differed significantly in axial diffusivity of the anterior CB and in fractional anisotropy of the superior CB. DTI metrics did not differ between the medicated group and the control group. Results suggest that the microstructure of the CB is altered in individuals with 22q11.2DS, and that those alterations may underlie positive prodromal symptoms of psychosis. Our findings further provide preliminary evidence that antipsychotic / mood stabilizer usage may have a reparative effect on white matter microstructure in prodromal 22q11.2DS, independent of the potential effects of psychosis. Future studies of white matter pathology in individuals with 22q11.2DS should test for potential effects of medication on white matter microstructure.
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影响因子：
4.5
作者：
Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
通讯作者：
Nuechterlein, Keith H.
DOI：
10.1111/j.1365-2788.2006.00859.x
发表时间：
2007-03-01
影响因子：
3.6
作者：
Antshel, K. M.;Stallone, K.;Kates, W. R.
通讯作者：
Kates, W. R.
DOI：
10.1176/appi.ajp.2013.12050674
发表时间：
2013-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen NC;Liu D;Ziebell S;Vora A;Ho BC
通讯作者：
Ho BC
DOI：
10.1016/j.cogbrainres.2005.09.013
发表时间：
2005-12-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Barnea-Goraly, N;Eliez, S;Reiss, AL
通讯作者：
Reiss, AL
影响因子：
14.5
作者：
Campbell, LE;Daly, E;Murphy, KC
通讯作者：
Murphy, KC