Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.
Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.
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DOI：
10.3390/ijerph18137170
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发表时间：
2021-07-04
影响因子：
--
通讯作者：
Conejo NM
中科院分区：
文献类型：
--
作者：
Pinos H;Carrillo B;Merchán A;Biosca-Brull J;Pérez-Fernández C;Colomina MT;Sánchez-Santed F;Martín-Sánchez F;Collado P;Arias JL;Conejo NM
近年来，全世界成人和儿童超重和肥胖的流行率急剧增加。关于肥胖症发病的传统模型是基于能量摄入和消耗之间的不平衡。然而，其他可能涉及的环境因素，如接触农药等化学品，不能被排除在外。这些化合物可以作为内分泌干扰化学品（EDC），可能会干扰与体重控制相关的几种机制相关的激素活性。本研究的主要目的是系统地审查科学文献中提供的数据，以了解产前和产后接触农药与后代肥胖之间可能存在的关联。共分析了25项人体研究和9项动物研究。本文综述了产前、围产期和产后有机磷、有机氯、拟除虫菊酯、烟碱类和氨基甲酸酯以及混合农药的暴露情况。这项系统性综述表明，农药暴露对体重的影响大多是不确定的，在人类和实验动物中发现了相互矛盾的结果。审查的结果取决于许多因素，包括给药剂量和途径、种属、性别和治疗持续时间。需要进行更多的研究，以有效评估不同农药的综合效应对人类健康的影响。
In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.
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DOI：
10.1016/j.reprotox.2020.06.011
发表时间：
2020-09
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Ganesan S;McGuire BC;Keating AF
通讯作者：
Keating AF
影响因子：
1.9
作者：
Cook, Laura E.;Finger, Bethany J.;Pask, Andrew J.
通讯作者：
Pask, Andrew J.
影响因子：
4.8
作者：
Grun, Felix;Blumberg, Bruce
通讯作者：
Blumberg, Bruce
影响因子：
8.3
作者：
Debost-Legrand, Anne;Warembourg, Charline;Cordier, Sylvaine
通讯作者：
Cordier, Sylvaine
影响因子：
7.9
作者：
Cowell WJ;Wright RJ
通讯作者：
Wright RJ