Crosslinking method of hyaluronic-based hydrogel for biomedical applications.
Crosslinking method of hyaluronic-based hydrogel for biomedical applications.
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DOI：
10.1177/2041731417726464
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发表时间：
2017-01
影响因子：
8.2
通讯作者：
Park H
中科院分区：
文献类型：
--
作者：
Khunmanee S;Jeong Y;Park H
在组织工程领域，需要超越常规支架和预成型水凝胶的进步。可注射水凝胶在研究人员中获得了更广泛的赞誉，因为它们可以用于微创外科手术。可注射的凝胶完全填充缺损区域并且具有良好的渗透性，因此是有前途的生物材料。该技术可以有效地应用于递送广泛的生物活性剂，如药物、蛋白质、生长因子，甚至活细胞。透明质酸因其独特的理化性质和生物学特性，在组织工程领域有着广阔的应用前景。因此，本文综述了使用不同的连接体进行化学和物理交联的各种方法，这些连接体已被研究用于开发透明质酸作为细胞支架、药物递送系统和伤口愈合应用中的可注射水凝胶的机械性能、生物降解性和生物相容性。
In the field of tissue engineering, there is a need for advancement beyond conventional scaffolds and preformed hydrogels. Injectable hydrogels have gained wider admiration among researchers as they can be used in minimally invasive surgical procedures. Injectable gels completely fill the defect area and have good permeability and hence are promising biomaterials. The technique can be effectively applied to deliver a wide range of bioactive agents, such as drugs, proteins, growth factors, and even living cells. Hyaluronic acid is a promising candidate for the tissue engineering field because of its unique physicochemical and biological properties. Thus, this review provides an overview of various methods of chemical and physical crosslinking using different linkers that have been investigated to develop the mechanical properties, biodegradation, and biocompatibility of hyaluronic acid as an injectable hydrogel in cell scaffolds, drug delivery systems, and wound healing applications.
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