Functional connectivity abnormalities vary by amygdala subdivision and are associated with psychiatric symptoms in unilateral temporal epilepsy.
Functional connectivity abnormalities vary by amygdala subdivision and are associated with psychiatric symptoms in unilateral temporal epilepsy.
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DOI：
10.1016/j.bandc.2013.08.001
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发表时间：
2013-11
影响因子：
2.5
通讯作者：
Tracy, Joseph I.
中科院分区：
文献类型：
--
作者：
Doucet, Gaelle E.;Skidmore, Christopher;Sharan, Ashwini D.;Sperling, Michael R.;Tracy, Joseph I.
杏仁核被描述为内侧颞叶癫痫（MTLE）影响的结构。事实上，研究表明杏仁核异常与MTLE中报告的共病抑郁和焦虑有关。在这种情况下，我们调查了功能连接（FC）出现在这个结构中的功能磁共振成像和抑郁和焦虑水平报告的MTLE患者之间的关系。我们专注于休息状态BOLD活动，并评估是否FC差异出现从三个杏仁核分区（外侧基底，中央和表面）在左侧和右侧MTLE组，与健康对照组相比。结果显示，患者组和对照组之间存在显着差异。具体而言，左侧MTLE组仅显示左侧种子的异常FC。此外，无论种子如何，我们观察到右侧MTLE组和对照组之间存在更可靠的差异。这些结果的进一步分析显示，这些受损的连接和精神症状之间的相关性在两个MTLE组。相反的关系，然而，突出显示：更抑郁或焦虑的右MTLE患者，更接近他们的FC值接近控制，而不那么焦虑的左MTLE患者，更接近他们的FC值是正常的。这些结果突出了MTLE如何改变从边缘系统出现的FC。总的来说，我们的数据表明，右颞叶癫痫对情绪相关网络的适应不良影响更大，具体到杏仁核区域，以及所涉及的情绪症状，比左颞叶癫痫。
The amygdala has been described as a structure affected by mesial temporal lobe epilepsy (MTLE). Indeed, it is suggested that amygdala abnormalities are related to the co-morbid depression and anxiety reported in MTLE. In this context, we investigated the relation between functional connectivity (FC) emerging from this structure in fMRI and depression and anxiety levels reported in MTLE patients. We focused on resting-state BOLD activity and evaluated whether FC differences emerge from each of three amygdala subdivisions (laterobasal, centromedial and superficial) in left and right MTLE groups, compared with healthy controls. Results revealed significant differences between patient groups and controls. Specifically, the left MTLE group showed abnormal FC for the left-sided seeds only. Furthermore, regardless of the seed, we observed more reliable differences between the right MTLE group and controls. Further analysis of these results revealed correlations between these impaired connectivities and psychiatric symptoms in both MTLE groups. Opposite relations, however, were highlighted: the more depressed or anxious the right MTLE patients, the closer their FC values approached controls; whereas the less anxious the left MTLE patients, the closer their FC values were normative. These results highlight how MTLE alter FC emerging from the limbic system. Overall, our data demonstrate that right TLE has a more maladaptive impact on emotion-related networks, in ways specific to the amygdala region, and the emotion symptom involved, than left TLE.
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影响因子：
5.6
作者：
Bonilha L;Edwards JC;Kinsman SL;Morgan PS;Fridriksson J;Rorden C;Rumboldt Z;Roberts DR;Eckert MA;Halford JJ
通讯作者：
Halford JJ
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
10.6
作者：
Frisch, Christian;Hanke, Joachim;Helmstaedter, Christoph
通讯作者：
Helmstaedter, Christoph
影响因子：
1.7
作者：
Killgore, WDS;Yurgelun-Todd, DA
通讯作者：
Yurgelun-Todd, DA
影响因子：
9.9
作者：
Bernasconi, N;Natsume, J;Bernasconi, A
通讯作者：
Bernasconi, A