Synthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent
Synthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent
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氟化银纳米颗粒的合成和表征及其作为非染色防龋剂的潜力
DOI：
10.2147/ijn.s243202
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发表时间：
2020-05
影响因子：
8
通讯作者：
Chun Hung Chu
中科院分区：
文献类型：
--
作者：
Iris Xiaoxue Yin;Irene Shuping Zhao;May Lei Mei;Edward Chin Man Lo;Jinyao Tang;Quanli Li;Lok Yan So;Chun Hung Chu
目标 本研究的第一个目标是制备含有不同浓度聚乙二醇包覆银纳米颗粒（PEG - AgNPs）的氟化钠（NaF）溶液。第二个目标是研究其对Str的抗菌活性。
（注：这里“Str”未明确具体所指，可能是某种细菌名称的缩写，需结合更多上下文确定准确含义。）
Objectives The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs). The second objective was to study the antibacterial activity against Streptococcus mutans and the tooth-staining effect of the solution. Methods PEG-AgNPs were prepared via the one-step chemical reduction of silver acetate with thiolated polyethylene glycol. The PEG-AgNPs were characterized with ultraviolet-visible spectrometry and transmission electron microscopy. The half maximal inhibitory concentration (IC50) for the PEG-AgNPs against Streptococcus mutans and human gingival fibroblasts (HGF-1) were determined. The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry. The IC50 of the fluoridated silver nanoparticles against Streptococcus mutans were measured. Results The PEG-AgNPs have an average diameter of 2.56±0.43 nm and showed excellent stability at high ionic strength (2.5% NaF) for 18 months. The IC50 of PEG-AgNPs against Streptococcus mutans was found to be 21.16±1.08 ppm silver, which was half of IC50 against HGF-1 cells (42.36±1.12 ppm), providing a working range to kill bacteria with no harm to human cells. The formulations with different concentrations of PEG-AgNPs showed no significant staining of teeth. Combining PEG-AgNPs with NaF significantly expanded the therapeutic window against Streptococcus mutans by reducing its IC50. Conclusion A biocompatible solution of NaF with PEG-AgNPs was developed. Because it has antibacterial activity against Streptococcus mutans and no tooth-staining effect, it can be used as an anti-caries agent.
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DOI：
10.3390/ma6062295
发表时间：
2013-06-05
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Reidy B;Haase A;Luch A;Dawson KA;Lynch I
通讯作者：
Lynch I
影响因子：
3.4
作者：
Ș. Marin;G. Vlăsceanu;R. Țiplea;Ioana Raluca Bucur;Mădălina Lemnaru;M. Marin;A. Grumezescu
通讯作者：
Ș. Marin;G. Vlăsceanu;R. Țiplea;Ioana Raluca Bucur;Mădălina Lemnaru;M. Marin;A. Grumezescu
影响因子：
4.4
作者：
S. Westland;W. Luo;Yuan Li;Q. Pan;A. Joiner
通讯作者：
S. Westland;W. Luo;Yuan Li;Q. Pan;A. Joiner
影响因子：
3.8
作者：
Kumari, Madhuree;Pandey, Shipra;Nautiyal, C. S.
通讯作者：
Nautiyal, C. S.
紫外辐照下芘对腐植酸还原银离子形成天然银纳米颗粒的影响
影响因子：
8.8
作者：
Min Liu;Xinyu Gao;Fei Pan;Yuwei Deng;Dongsheng Xia;Zhang Li;Jie Fu
通讯作者：
Jie Fu