Fabrication of Hybrid Materials from Titanium Dioxide and Natural Phenols for Efficient Radical Scavenging against Oxidative Stress.
Fabrication of Hybrid Materials from Titanium Dioxide and Natural Phenols for Efficient Radical Scavenging against Oxidative Stress.
复制标题
用二氧化钛和天然酚制备混合材料，用于有效清除自由基以对抗氧化应激。
DOI：
10.1021/acsbiomaterials.9b00535
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发表时间：
2019
影响因子：
5.8
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Yu H
自由基引起的氧化应激是造成细胞内损伤的主要威胁之一。在这里，我们报告了一个方便的方法来合成，表征和评价钛基复合材料的自由基活性。我们研究了天然抗氧化剂（姜黄素，槲皮素，儿茶素和维生素E）作为自由基清除剂和稳定剂的潜力。采用溶胶-凝胶法、羧化法和酯化法制备了二氧化钛复合材料。采用FTIR、PXRD、UV-vis和SEM等方法对钛-苯酚复合材料进行了表征。使用DPPH和使用离体大鼠肝线粒体的体外LPO测定来评估新材料的自由基清除能力。与裸TiO 2相比，新材料表现出更高的稳定性和抗氧化活性。发现姜黄素和槲皮素基复合物在所研究的复合物中显示出最高的抗氧化效率，其次是儿茶素和维生素E基材料。在Caco-2细胞系上进行的MTT测定的结果表明，该复合材料在体外不具有细胞毒性。这项研究表明，强大的抗氧化剂与二氧化钛的组合可以改变其功能特性，并提供一种对抗氧化应激的方便策略。
Oxidative stress caused by free radicals is one of the great threats to inflict intracellular damage. Here, we report a convenient approach to the synthesis, characterization, and evaluation of the radical activity of titanium-based composites. We have investigated the potential of natural antioxidants (curcumin, quercetin, catechin, and vitamin E) as radical scavengers and stabilizers. The titanium oxide composites were prepared via three steps including sol–gel synthesis, carboxylation, and esterification. The characterization of the titanium–phenol composites was carried out by FTIR, PXRD, UV–vis and SEM methods. The radical scavenging ability of the novel materials was evaluated using DPPH and an in vitro LPO assay using isolated rat liver mitochondria. The novel materials exhibit both a higher stability and an antioxidant activity in comparison to bare TiO2. It was found that curcumin and quercetin based composites show the highest antioxidant efficiency among the composites under study followed by catechin and vitamin E based materials. The results from an MTT assay carried out on the Caco-2 cell line indicate that the composites do not contribute to the cytotoxicity in vitro. This study demonstrates that a combination of powerful antioxidants with titanium dioxide can change its functional properties and provide a convenient strategy against oxidative stress.
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影响因子：
5
作者：
Jugan, Mary-Line;Barillet, Sabrina;Carriere, Marie
通讯作者：
Carriere, Marie
DOI：
10.1016/0005-2736(91)90165-5
发表时间：
1991-11-18
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
ALVAREZHERNANDEZ, X;NICHOLS, GM;GLASS, J
通讯作者：
GLASS, J
类黄酮代谢物与过氧亚硝酸盐的反应。
影响因子：
3.1
作者：
Susan E Pollard;G. Kuhnle;Dr David Vauzour;K. Vafeiadou;X. Tzounis;M. Whiteman;C. Rice;J. Spencer
通讯作者：
J. Spencer
影响因子：
3.8
作者：
Maynard, Andrew D.;Warheit, David B.;Philbert, Martin A.
通讯作者：
Philbert, Martin A.
影响因子：
5.3
作者：
Uttara B;Singh AV;Zamboni P;Mahajan RT
通讯作者：
Mahajan RT