Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York.
Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York.
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DOI：
10.1080/15287394.2012.688485
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Louis ED;Jiang W;Gerbin M;Viner AS;Factor-Litvak P;Zheng W
原发性震颤(ET)是一种广泛存在的晚期神经系统疾病。遗传和环境因素可能起到重要的致病作用。Harmane(1-甲基-9H-吡啶并[3，4-b]吲哚)是一种产生震颤的强效神经毒素。以前，与对照组相比，ET患者的血液HARM浓度升高，但这些观察都是横断面的，只在一个时间点评估每个受试者。因此，从来没有人在同一受试者身上重复检测过两次血液哈特曼。观察到的病例对照差异是否会在多年后的第二个时间点持续，目前尚不清楚。目前的目标是重新评估我们的ET病例和对照样本，以确定在第二个时间点ET患者的血液HARM浓度是否保持高水平。采用高效液相色谱法测定63例ET患者和70例对照组的血HARM浓度。最初和随后的血液毒性测定之间的平均时间为6年。病例组对数血HARM浓度为(0.30±0.61)g−10/m l，高于对照组(0.0 8±0.5 5 g−10/m l)，中位数为0.2 2 g−10/m l对0.11 g−10/m l，有ET家族史者最高。在几年后的第二个时间点重新评估时，ET病例的血液Harmane浓度高于对照组，表明这种环境毒素与ET之间似乎存在稳定的联系。
Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors are likely to play important etiological roles. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin. Previously, elevated blood harmane concentrations were demonstrated in ET cases compared to controls, but these observations were all been cross-sectional, assessing each subject at only one time point. Thus, no one has ever repeat-assayed blood harmane in the same subjects twice. Whether the observed case-control difference persists at a second time point, years later, is unknown. The current goal was to re-assess a sample of our ET cases and controls to determine whether blood harmane concentration remained elevated in ET at a second time point. Blood harmane concentrations were quantified by a well-established high performance liquid chromatography method in 63 ET cases and 70 controls. A mean of approximately 6 years elapsed between the initial and this subsequent blood harmane determination. The mean log blood harmane concentration was significantly higher in cases than controls (0.30 ± 0.61 g−10/ml vs. 0.08 ± 0.55 g−10/ml), and the median value in cases was double that of controls: 0.22 g−10/ml vs. 0.11 g−10/ml. The log blood harmane concentration was highest in cases with a family history of ET. Blood harmane concentration was elevated in ET cases compared to controls when re-assessed at a second time point several years later, indicating what seems to be a stable association between this environmental toxin and ET.
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