Alterations in CRY2 and PER3 gene expression associated with thalamic-limbic community structural abnormalities in patients with bipolar depression or unipolar depression.
Alterations in CRY2 and PER3 gene expression associated with thalamic-limbic community structural abnormalities in patients with bipolar depression or unipolar depression.
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CRY2 和 PER3 基因表达的改变与双相抑郁症或单相抑郁症患者的丘脑边缘群落结构异常相关。
DOI：
10.1016/j.jad.2021.10.125
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发表时间：
2021-10
影响因子：
6.6
通讯作者：
Li Tao
中科院分区：
文献类型：
--
作者：
Zhang Chengcheng;Ni Peiyan;Liang Sugai;Li Xiaojing;Tian Yang;Du Xiangdong;Wei Wei;Meng Yajing;Wei Jinxue;Ma Xiaohong;Deng Wei;Guo Wanjun;Li Mingli;Yu Hua;Zhao Liansheng;Wang Qiang;Pak Sham C;Li Tao
目的探讨双相抑郁症（BDP）和单相抑郁症（UDP）患者的脑结构异常及其与昼夜节律基因表达的关系。方法93例受试者，其中双相抑郁症（BDP）32例，单相抑郁症（UDP）26例，健康对照组35例。获得脑结构磁共振成像扫描，并使用优化的基于体素的形态测量来探索区域灰质体积（GMV）的组间差异。外周血中的昼夜节律基因的mRNA表达水平进行了测定，使用逆转录定量实时聚合酶链反应。结果我们的研究结果表明，GMV在大脑区域中的丘脑-边缘系统的途径有显着增加的BDP患者相比，对照组，而增加的GMV在UDP患者相比，对照组仅限于丘脑。与对照组相比，BDP患者的昼夜节律相关基因的mRNA表达水平显著降低，而UDP患者的昼夜节律相关基因的mRNA表达水平显著升高。此外，UDP患者右侧丘脑GMV与PER 3 mRNA水平呈正相关，而BDP患者右侧海马GMV与PER 3 mRNA水平呈负相关。结论BDP和MDD患者均存在右侧丘脑GMV异常。PER 3和PER 12基因可能分别对BDP的右侧海马功能障碍和UDP的右侧丘脑功能障碍起关键作用。这一结果为情绪障碍的治疗提供了潜在的重要分子靶点。
Objectives The current study aimed to identify shared and distinct brain structure abnormalities and their relationships with the expression of circadian genes in patients with bipolar or unipolar depression.Method A total of 93 subjects participated in this study, including 32 patients with bipolar depression (BDP), 26 patients with unipolar depression (UDP) and 35 age- and sex-matched healthy controls. Brain structural magnetic resonance imaging scans were obtained, and optimized voxel-based morphometry was used to explore group differences in regional gray matter volume (GMV). The mRNA expression levels of circadian genes in peripheral blood were measured using reverse transcription quantitative real-time polymerase chain reaction.Results Our results showed that the GMV in brain regions in the thalamus-limbic pathways had significantly increased in the BDP patients compared to controls, while the increased GMV in UDP patients compared to controls was limited to the thalamus. The mRNA expression levels of circadian-related genes decreased significantly in patients with BDP, but increased in patients with UDP, compared to controls. In addition, the GMV in the right thalamus in the patients with UDP was positively associated with mRNA levels of CRY2, while the GMV in the right hippocampus in the patients with BDP was negatively associated with mRNA levels of PER3.Conclusion Our study suggested that patients with BDP or MDD shared GMV abnormalities in the right thalamus. The PER3 and CRY2 genes might be critical to right hippocampal dysfunction in BDP and right thalamic dysfunction in UDP, respectively. The result provided potentially important molecular targets for the treatment of mood disorders.
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影响因子：
2.5
作者：
VOGT, BA;PANDYA, DN;ROSENE, DL
通讯作者：
ROSENE, DL
影响因子：
4.4
作者：
Schaufler J;Ronovsky M;Savalli G;Cabatic M;Sartori SB;Singewald N;Pollak DD
通讯作者：
Pollak DD
影响因子：
3.7
作者：
Matsubara T;Matsuo K;Harada K;Nakano M;Nakashima M;Watanuki T;Egashira K;Furukawa M;Matsunaga N;Watanabe Y
通讯作者：
Watanabe Y
一种复合外周血基因表达度量是双相情感障碍中潜在的诊断生物标志物。
影响因子：
6.8
作者：
Munkholm K;Peijs L;Vinberg M;Kessing LV
通讯作者：
Kessing LV
影响因子：
2.3
作者：
Lacerda, ALT;Nicoletti, MA;Soares, JC
通讯作者：
Soares, JC