Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders.
Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders.
复制标题
DOI：
10.1371/journal.pone.0168493
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Matsubara T;Matsuo K;Harada K;Nakano M;Nakashima M;Watanuki T;Egashira K;Furukawa M;Matsunaga N;Watanabe Y
关于双相情感障碍（BD）和重性抑郁症（MDD）的疾病特异性生物标志物知之甚少。我们的目的是确定一个神经基板，可用于区分BD从MDD。我们的研究包括BD组（10例BD患者，10例BD患者的一级亲属），MDD组（17例MDD患者，17例MDD患者的一级亲属）和27名健康人。结构和功能的大脑异常进行了评估，体素为基础的形态学和连线测试（TMT），分别。BD组在前扣带回皮质（ACC; p = 0.01）和左侧大脑皮层（p < 0.01）的灰质（GM）体积中显示出显著的诊断主效应。BD患者的FDR显示左侧ACC GM体积显著小于健康受试者（p < 0.01），BD患者的ACC（p < 0.01）和左侧岛叶GM体积显著小于健康受试者（p < 0.01）。MDD组在左右岛叶GM体积中显示出诊断的主要影响趋势。BD组左岛GM体积与TMT-A评分呈显著负相关（p < 0.05）。我们的研究结果表明，ACC体积可能是一个独特的内表型的BD，而岛体积可能是一个共享的BD和MDD内表型。此外，脑卒中可能与BD的认知功能下降和预后不良有关。
Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively. The BD group showed a significant main effect of diagnosis in the gray matter (GM) volume of the anterior cingulate cortex (ACC; p = 0.01) and left insula (p < 0.01). FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects (p < 0.01), and patients with BD showed significantly smaller ACC (p < 0.01) and left insular GM volume (p < 0.01) than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores (p < 0.05). Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD.
登录
查看更多内容
影响因子：
6.6
作者：
Gohier, Benedicte;Ferracci, Laetitia;Le Gall, Didier
通讯作者：
Le Gall, Didier
影响因子：
4.8
作者：
Baare, William F. C.;Vinberg, Maj;Kessing, Lars Vedel
通讯作者：
Kessing, Lars Vedel
影响因子：
4.3
作者：
Du, Mingying;Liu, Jia;Gong, Qiyong
通讯作者：
Gong, Qiyong
影响因子：
4.8
作者：
Giakoumatos, Christoforos I.;Tandon, Neeraj;Shah, Jai;Mathew, Ian T.;Brady, Roscoe O.;Clementz, Brett A.;Pearlson, Godfrey D.;Thaker, Gunvant K.;Tamminga, Carol A.;Sweeney, John A.;Keshavan, Matcheri S.
通讯作者：
Keshavan, Matcheri S.
影响因子：
10.6
作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
通讯作者：
Soares, Jair C.