Defining adrenarche in the rhesus macaque (Macaca mulatta), a non-human primate model for adrenal androgen secretion.
Defining adrenarche in the rhesus macaque (Macaca mulatta), a non-human primate model for adrenal androgen secretion.
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DOI：
10.1016/j.mce.2010.12.022
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发表时间：
2011-04-10
影响因子：
4.1
通讯作者：
Abbott DH
中科院分区：
文献类型：
--
作者：
Conley AJ;Moeller BC;Nguyen AD;Stanley SD;Plant TM;Abbott DH
肾上腺初显，定义为青春期前肾上腺雄激素分泌的增加，由网状腺（ZR）成熟引起，被认为只发生在人类和一些类人猿中。在恒河猴中，循环脱氢表雄酮（DHEA）或其磺基共轭物（DHEAS）的研究未能证明青春期前升高的典型人类肾上腺素初显，但现有的数据是横截面，包括少数新生儿或早期婴儿样本。然而，根据形态学和生化分析，3个月龄的恒河猴婴儿的ZR成熟是完全的。此外，初步纵向研究从出生到婴儿期的去势雄性，和完整的男性和女性，第一次表明，有一个短暂的，青春期前的恒河猴肾上腺雄激素的升高。血清DHEAS浓度增加，峰值之间的6和8周龄的去势男性，和完整的男性和女性，然后下降。这些纵向配置文件添加内分泌支持的形态和生化证据，肾上腺初显发生在一个狭窄的发育窗口，在婴儿恒河猴。任何物种中的肾上腺初长，只有在ZR成熟的形态学和生物化学证据表明的发育阶段进行了仔细的纵向激素分析后才能确定。
Adrenarche, defined as a prepubertal increase in adrenal androgen secretion resulting from zona reticularis (ZR) maturation, is thought to occur only in humans and some Great Apes. In the rhesus macaque, studies of circulating dehydroepiandrosterone (DHEA) or its sulpho-conjugate (DHEAS) have failed to demonstrate a prepubertal rise typical of human adrenarche, but available data are cross-sectional and include few neonatal or early infant samples. However, ZR maturation is complete in rhesus infants by 3 months of age based on morphological and biochemical analyses. Furthermore, preliminary longitudinal study from birth through infancy of castrated males, and intact males and females, suggests for the first time that there is a transient, prepubertal elevation of adrenal androgen in rhesus macaques. Serum DHEAS concentration increased, peaking between 6 and 8 weeks of age in castrate males, and intact males and females, then declined. These longitudinal profiles add endocrinological support to the morphological and biochemical evidence that adrenarche occurs in a narrow developmental window in infant rhesus macaques. Adrenarche in any species should be defined only after careful longitudinal hormone analysis have been conducted in stages of development that are suggested by morphological and biochemical evidence of ZR maturation.
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影响因子：
39.2
作者：
ALBRIGHT, F
通讯作者：
ALBRIGHT, F
影响因子：
5.8
作者：
Crawford, Sybil;Santoro, Nanette;Lasley, Bill
通讯作者：
Lasley, Bill
影响因子：
5.8
作者：
Lane, MA;Ingram, DK;Roth, GS
通讯作者：
Roth, GS
影响因子：
4.8
作者：
Auchus, RJ;Lee, TC;Miller, WL
通讯作者：
Miller, WL
DOI：
10.1016/0006-291x(82)91877-0
发表时间：
1982-01-01
影响因子：
3.1
作者：
KATAGIRI, M;SUHARA, K;FUJIMURA, Y
通讯作者：
FUJIMURA, Y