Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice.
Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice.
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DOI：
10.1038/s41398-021-01458-9
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发表时间：
2021-05-26
影响因子：
6.8
通讯作者：
Wotjak CT
中科院分区：
文献类型：
--
作者：
Heinz DE;Schöttle VA;Nemcova P;Binder FP;Ebert T;Domschke K;Wotjak CT
啮齿类动物的焦虑行为经常伴随着探索性的减少。在这里，我们确定了焦虑、恐惧和饱足和觅食小鼠的探索动力的可分离成分。借助行为分析，包括开阔场地任务、高架加迷宫任务、暗-光转换任务和甲虫狂热任务，我们证明了通过限制食物来进行探索的普遍增加。为高焦虑行为(HAB)而培育的限食小鼠表现出改善的焦虑--但不是与恐惧相关的行为。通过主成分分析，我们确定了三个独立的成分，它们与Gray的强化敏感性理论提出的行为维度(接近行为、回避行为和决策行为)相似。综上所述，我们在焦虑障碍的小鼠模型中展示了限制食物的焦虑后果，这种焦虑障碍可以与觅食行为的普遍增加分离。
Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice. With the help of behavioral assays, including the open field task, elevated plus maze, dark–light transition task, and beetle mania task, we demonstrate a general increase in exploration by food restriction. Food-restricted mice bred for high anxiety behavior (HAB) showed ameliorated anxiety- but not fear-related behavior. By means of principal component analysis, we identified three independent components, which resemble the behavioral dimensions proposed by Gray’s Reinforcement Sensitivity Theory (approach behavior, avoidance behavior, and decision making). Taken together, we demonstrate anxiolytic consequences of food restriction in a mouse model of anxiety disorders that can be dissociated from a general increase in foraging behavior.
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影响因子：
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通讯作者：
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