Outbreak of variant influenza A(H3N2) virus in the United States.
Outbreak of variant influenza A(H3N2) virus in the United States.
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DOI：
10.1093/cid/cit649
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Finelli L
中科院分区：
文献类型：
--
作者：
Jhung MA;Epperson S;Biggerstaff M;Allen D;Balish A;Barnes N;Beaudoin A;Berman L;Bidol S;Blanton L;Blythe D;Brammer L;D'Mello T;Danila R;Davis W;de Fijter S;Diorio M;Durand LO;Emery S;Fowler B;Garten R;Grant Y;Greenbaum A;Gubareva L;Havers F;Haupt T;House J;Ibrahim S;Jiang V;Jain S;Jernigan D;Kazmierczak J;Klimov A;Lindstrom S;Longenberger A;Lucas P;Lynfield R;McMorrow M;Moll M;Morin C;Ostroff S;Page SL;Park SY;Peters S;Quinn C;Reed C;Richards S;Scheftel J;Simwale O;Shu B;Soyemi K;Stauffer J;Steffens C;Su S;Torso L;Uyeki TM;Vetter S;Villanueva J;Wong KK;Shaw M;Bresee JS;Cox N;Finelli L
在H3N2v变异流感爆发期间，我们在10个州发现了306例病例。大多数病例报告在患病前参加农业博览会和/或接触过猪。我们没有发现H3N2v有效或持续的人际传播的证据。 变异流感病毒感染是罕见的，但如果人与人之间的传播是有效的，可能有大流行的潜力。 我们描述了2011年首次发现的甲型H3N2流感变异病毒（H3N2v）多州爆发的流行病学。 方法：我们确定了实验室确诊的H3N2v病例，并使用标准病例报告表来描述疾病和暴露情况。 我们认为，如果在发病前4天内没有发现与猪的接触，则疾病是由人与人之间的H3N2v传播引起的。 结果：从2012年7月9日至9月7日，我们在10个州发现了306例H3N2v病例。 所有患者的中位年龄为7岁。常见的体征和症状包括发热（98%）、咳嗽（85%）和疲劳（83%）。16例患者（5.2%）住院，确定了1例致死性病例。大多数感染者报告在患病前参加农业博览会（93%）和/或接触猪（95%）。我们确定了15例可能的人与人之间传播H3N2v的病例。从病人身上回收的病毒与从以前的H3N2v病例中回收的病毒有93%-100%的相同和相似性。所有检测的H3N2v病毒对奥司他韦和扎那米韦敏感，对金刚烷类抗病毒药物耐药。 结论：在变异型流感的大爆发中，大多数感染者报告了接触，这表明在农业博览会上与猪接触是H3N2v感染的一个风险。 我们发现H3N2v病毒存在有限的人际传播，但没有发现有效或持续的人际传播证据。展会管理人员和与会者应意识到在这些环境中猪到人传播流感病毒的风险。
During an outbreak of H3N2v variant influenza, we identified 306 cases in ten states. Most cases reported agricultural fair attendance and/or contact with swine prior to illness. We found no evidence of efficient or sustained person-to-person transmission of H3N2v. Background. Variant influenza virus infections are rare but may have pandemic potential if person-to-person transmission is efficient. We describe the epidemiology of a multistate outbreak of an influenza A(H3N2) variant virus (H3N2v) first identified in 2011. Methods. We identified laboratory-confirmed cases of H3N2v and used a standard case report form to characterize illness and exposures. We considered illness to result from person-to-person H3N2v transmission if swine contact was not identified within 4 days prior to illness onset. Results. From 9 July to 7 September 2012, we identified 306 cases of H3N2v in 10 states. The median age of all patients was 7 years. Commonly reported signs and symptoms included fever (98%), cough (85%), and fatigue (83%). Sixteen patients (5.2%) were hospitalized, and 1 fatal case was identified. The majority of those infected reported agricultural fair attendance (93%) and/or contact with swine (95%) prior to illness. We identified 15 cases of possible person-to-person transmission of H3N2v. Viruses recovered from patients were 93%–100% identical and similar to viruses recovered from previous cases of H3N2v. All H3N2v viruses examined were susceptible to oseltamivir and zanamivir and resistant to adamantane antiviral medications. Conclusions. In a large outbreak of variant influenza, the majority of infected persons reported exposures, suggesting that swine contact at an agricultural fair was a risk for H3N2v infection. We identified limited person-to-person H3N2v virus transmission, but found no evidence of efficient or sustained person-to-person transmission. Fair managers and attendees should be aware of the risk of swine-to-human transmission of influenza viruses in these settings.
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DOI：
10.1093/cid/cit273
发表时间：
2013-07
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Biggerstaff M;Reed C;Epperson S;Jhung MA;Gambhir M;Bresee JS;Jernigan DB;Swerdlow DL;Finelli L
通讯作者：
Finelli L
过去、现在和未来可能的人类感染甲型流感病毒 H7 亚型。
影响因子：
11.8
作者：
Belser, Jessica A.;Bridges, Carolyn B.;Katz, Jacqueline M.;Tumpey, Terrence M.
通讯作者：
Tumpey, Terrence M.
影响因子：
6.7
作者：
Barman S;Krylov PS;Fabrizio TP;Franks J;Turner JC;Seiler P;Wang D;Rehg JE;Erickson GA;Gramer M;Webster RG;Webby RJ
通讯作者：
Webby RJ
影响因子：
5.4
作者：
Houser, Katherine V.;Katz, Jacqueline M.;Tumpey, Terrence M.
通讯作者：
Tumpey, Terrence M.
影响因子：
11.8
作者：
Donnelly, Christl A.;Finelli, Lyn;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.