Structure, function and connectivity fingerprints of the frontal eye field versus the inferior frontal junction: A comprehensive comparison.
Structure, function and connectivity fingerprints of the frontal eye field versus the inferior frontal junction: A comprehensive comparison.
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DOI：
10.1111/ejn.15393
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发表时间：
2021-08
影响因子：
3.4
通讯作者：
Baldauf, Daniel
中科院分区：
文献类型：
--
作者：
Bedini, Marco;Baldauf, Daniel
关键词：
人类的前额叶皮层包含两个突出的区域，即额叶眼区和下额叶交界区，它们在注意力、工作记忆和认知控制的协调功能中起着至关重要的作用。受非人类灵长类动物的比较证据的启发，我们回顾了人类神经影像学文献，表明这些区域的功能可以明显分离。我们发现这些区域与感觉域和视觉地形图、自上而下和自下而上的空间注意力、空间与非空间（即，基于特征和对象的注意力和工作记忆，最后是多需求系统。使用多变量模式分析的功能磁共振成像（fMRI）研究分别揭示了额叶眼野和下额叶交界区对空间和非空间信息的选择性。功能和有效连接的分析提供了证据的调节下游视觉区的活动，从额眼场和额下交界处，并揭示了他们的相互影响。因此，我们建议未来的研究应该更明确地解开这些区域在空间和非空间选择控制中的作用。我们建议，结构和功能连接性的分析（即，额叶眼区和下额叶交界处的连通性指纹（连接性指纹）可以用于进一步表征它们分别参与空间（“在哪里”）和非空间（“什么”）网络，突出分离的大脑网络，其允许偏置视觉选择和工作记忆表现以支持目标驱动的行为。涉及空间机制的范例（红色轮廓）始终参与额眼场。相比之下，旨在解开非空间（即，基于特征和对象的）机制与空间机制（蓝色轮廓）主要涉及额下交界处。我们研究了这些区域的结构，功能和连接指纹的系统差异是如何支撑这种跨注意力，工作记忆和认知控制功能的关键分离的。
The human prefrontal cortex contains two prominent areas, the frontal eye field and the inferior frontal junction, that are crucially involved in the orchestrating functions of attention, working memory and cognitive control. Motivated by comparative evidence in non‐human primates, we review the human neuroimaging literature, suggesting that the functions of these regions can be clearly dissociated. We found remarkable differences in how these regions relate to sensory domains and visual topography, top‐down and bottom‐up spatial attention, spatial versus non‐spatial (i.e., feature‐ and object‐based) attention and working memory and, finally, the multiple‐demand system. Functional magnetic resonance imaging (fMRI) studies using multivariate pattern analysis reveal the selectivity of the frontal eye field and inferior frontal junction to spatial and non‐spatial information, respectively. The analysis of functional and effective connectivity provides evidence of the modulation of the activity in downstream visual areas from the frontal eye field and inferior frontal junction and sheds light on their reciprocal influences. We therefore suggest that future studies should aim at disentangling more explicitly the role of these regions in the control of spatial and non‐spatial selection. We propose that the analysis of the structural and functional connectivity (i.e., the connectivity fingerprints) of the frontal eye field and inferior frontal junction may be used to further characterize their involvement in a spatial (‘where’) and a non‐spatial (‘what’) network, respectively, highlighting segregated brain networks that allow biasing visual selection and working memory performance to support goal‐driven behaviour. Paradigms that involve spatial mechanisms (red outline) consistently engage the frontal eye field. In contrast, paradigms designed to disentangle non‐spatial (i.e., feature‐ and object‐based) mechanisms from spatial ones (blue outline) predominantly engage the inferior frontal junction. We examine how systematic differences in the structure, function and connectivity fingerprints of these regions underlie this crucial dissociation across attention, working memory and cognitive control functions.
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