Systematic review of the relationship between family history and lung cancer risk.

Systematic review of the relationship between family history and lung cancer risk.
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对家族史与肺癌风险之间关系的系统评价。

DOI:
10.1038/sj.bjc.6602769
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发表时间:
2005-10-03
影响因子:
8.8
通讯作者:
Houlston, RS
Houlston, RS
中科院分区:
医学1区
文献类型:
--
作者:
Matakidou, A;Eisen, T;Houlston, RS

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我们对28项病例对照、17项队列和7项双胞胎研究进行了系统回顾,探讨了家族史与肺癌风险之间的关系,并对风险估计进行了荟萃分析。来自病例对照和队列研究的数据显示,与受影响的亲属相关的肺癌风险显着增加。在年轻时被诊断出的病例的亲属和有多名受影响家庭成员的人中,风险似乎更大。肺癌风险增加与受影响的配偶和双胞胎研究有关,虽然有限,但有利于共同的环境暴露。目前发表的流行病学研究的局限性,以推断遗传易感性进行了讨论。
We performed a systematic review of 28 case–control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case–control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.
DOI: 10.1002/ijc.10332
发表时间: 2002-05-10
影响因子: 6.4
作者:
Czene, K;Lichtenstein, P;Hemminki, K
通讯作者: Hemminki, K
DOI: 10.1002/ijc.10764
发表时间: 2003-01-01
影响因子: 6.4
作者:
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通讯作者: Lit, XJ
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发表时间: 2002-11-10
影响因子: 6.4
作者:
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通讯作者: Li, XJ
DOI: 10.1056/nejm199209173271201
发表时间: 1992-09-17
影响因子: 158.5
作者:
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通讯作者: FABSITZ, R
DOI: 10.1016/0197-2456(86)90046-2
发表时间: 1986-09-01
期刊: CONTROLLED CLINICAL TRIALS
影响因子: --
作者:
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通讯作者: LAIRD, N