Covariation Between Brain Function (MEG) and Structure (DTI) Differentiates Adolescents with Fetal Alcohol Spectrum Disorder from Typically Developing Controls.
Covariation Between Brain Function (MEG) and Structure (DTI) Differentiates Adolescents with Fetal Alcohol Spectrum Disorder from Typically Developing Controls.
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DOI：
10.1016/j.neuroscience.2020.09.053
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发表时间：
2020-11-21
期刊：
影响因子：
3.3
通讯作者：
Stephen JM
中科院分区：
文献类型：
--
作者：
Pinner JFL;Coffman BA;Stephen JM
产前暴露于酒精的个体所经历的行为、认知和感觉困难目前无法提供胎儿酒精谱系障碍（FASD）的早期识别。为了进一步推进这一研究，我们收集了12-21岁青少年（FASD: N=13; HC: N=20）在听觉、体感、视觉范式、DTI和行为方面的MEG数据。我们利用联合独立成分分析（jICA）评估了脑功能（MEG）和结构（FA）之间的关系，并研究了这种测量与行为的关系。我们确定了5个成分，揭示了MEG和FA之间共变异的组差异。例如，成分5 （t=3.162, p=0.003, Hedges ' g=1.13）包含与所有三种感觉模式相对应的MEG活动，最强烈的是枕叶，以及dti衍生的小脑FA，这是小脑在感觉加工中的作用。此外，在HCs中，成分5的负荷因子与言语能力呈正相关（r=0.646, p=0.002），说明协变越高，言语表现越好。有趣的是，这种关系在FASD中缺乏（r=0.009, p=0.979）。成分5负荷因子与冲动性呈负相关（r= - 0.527, p=0.002），表明较强的功能-结构关联与冲动性较低的个体相关。这些发现表明MEG和FA的多模态整合在结构和功能之间提供了新的联系，可能有助于区分青少年FASD和HC。
The behavioral, cognitive, and sensory difficulties experienced by individuals exposed to alcohol prenatally currently fail to provide early identification for fetal alcohol spectrum disorder (FASD). Attempting to advance this pursuit through a multivariate analysis, we collected MEG data during auditory, somatosensory, visual paradigms, DTI, and behavior in adolescents ages 12–21 years (FASD: N=13; HC: N=20). We assessed the relationship between brain function (MEG) and structure (FA) utilizing joint independent component analysis (jICA), and examined how this measure relates to behavior. We identified 5 components that reveal group differences in co-variation between MEG and FA. For example, component 5 (t=3.162, p=0.003, Hedges’ g=1.13) contained MEG activity corresponding to all three sensory modalities, most robustly in occipital lobes, and DTI-derived cerebellar FA, underlying the role of the cerebellum in sensory processing. Further, in HCs component 5’s loading factor was positively correlated with verbal ability (r=0.646, p=0.002), indicating higher covariation was associated with better verbal performance. Interestingly, this relationship is lacking in FASD (r=0.009, p=0.979). Also, component 5 loading factor negatively correlated with impulsivity (r=−0.527, p=0.002), indicating that stronger function-structure associations were associated with individuals with lower impulsivity. These findings suggest that multimodal integration of MEG and FA provides novel associations between structure and function that may help differentiate adolescents with FASD from HC.
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