Designing multifunctional quantum dots for bioimaging, detection, and drug delivery.
Designing multifunctional quantum dots for bioimaging, detection, and drug delivery.
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DOI：
10.1039/b915139g
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发表时间：
2010-11
影响因子：
46.2
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Zrazhevskiy P;Sena M;Gao X
The emerging field of bionanotechnology aims at revolutionizing biomedical research and clinical practice via introduction of nanoparticle-based tools, expanding capabilities of existing investigative, diagnostic, and therapeutic techniques as well as creating novel instruments and approaches for addressing challenges faced by medicine. Quantum dots (QDs), semiconductor nanoparticles with unique photo-physical properties, have become one of the dominant classes of imaging probes as well as universal platforms for engineering of multifunctional nanodevices. Possessing versatile surface chemistry and superior optical features, QDs have found initial use in a variety of in vitro and in vivo applications. However, careful engineering of QD probes guided by application-specific design criteria is becoming increasingly important for successful transition of this technology from proof-of-concept studies towards real-life clinical applications. This review outlines the major design principles and criteria, from general ones to application-specific, governing the engineering of novel QD probes satisfying the increasing demands and requirements of nanomedicine and discusses the future directions of QD-focused bionanotechnology research (critical review, 201 references).
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DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
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通讯作者：
Ruoslahti, E
影响因子：
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10.8
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Bagalkot, Vaishali;Zhang, Liangfang;Farokhzad, Omid C.
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Farokhzad, Omid C.
影响因子：
4.9
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All-Jamal, Wafa' T.;Al-Jamal, Khuloud T.;Kostarelos, Kostas
通讯作者：
Kostarelos, Kostas