Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: a U.S. population-based study of racial and ethnic groups.
Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: a U.S. population-based study of racial and ethnic groups.
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DOI：
10.1002/ijc.29237
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发表时间：
2015-03-01
影响因子：
6.4
通讯作者：
Freedman, D. Michal
中科院分区：
文献类型：
--
作者：
Cahoon, Elizabeth K.;Pfeiffer, Ruth M.;Wheeler, David C.;Arhancet, Juan;Lin, Shih-Wen;Alexander, Bruce H.;Linet, Martha S.;Freedman, D. Michal
紫外线辐射（UVR）暴露和非霍奇金淋巴瘤（NHL）之间的关联一直不一致，但很少有研究检查特定亚型或跨种族/种族的这些关联。我们评估了2001-2010年美国白人、西班牙裔和黑人（n= 187，778例病例）环境UVR暴露与亚型特异性NHL发病率之间的关系。使用泊松回归计算UVR五分位数的发病率比（IRR）和95%置信区间（CI）。慢性/小淋巴细胞/白血病（CLL/SLL）的最高UVR五分位数的发病率较低（IRR= 0.87，95% CI：0.77-0.97），套细胞（IRR= 0.82，95% CI：0.69，0.97），淋巴浆细胞性（IRR= 0.58，95% CI：0.42-0.80），粘膜相关淋巴组织（MZLMALT）（IRR= 0.74，95% CI：0.60-0.90），滤泡（FL）（IRR= 0.76，95% CI：0.68-0.86），弥漫性大B细胞（IRR= 0.84，95% CI：0.76-0.94;），外周T细胞，其他（PTCL）（IRR= 0.76，95% CI：0.61-0.95）和未另行说明的PTCL（PNOS）（IRR= 0.77，95% CI：0.61-0.98）。MZLMALT、FL、DLBCL、BNOS和PTCL的趋势显著，其中FL和DLBCL在Bonferroni校正后仍然显著。我们发现CLL/SLL、FL、Burkitt、PNOS和MF/SS的种族/民族相互作用，在Bonferroni校正后CLL/SLL和FL仍然显著。一些B细胞淋巴瘤（CLL/SLL，FL，Burkitt）在白人和西班牙裔美国人中显示出显着的反向关系，但不是黑人。一些T细胞淋巴瘤表明，黑人中紫外线辐射最高五分位数（PNOS和MF/SS）的风险降低最多，尽管趋势并不显著。这些发现加强了UVR暴露负相关的情况，支持NHL亚型之间的适度异质性，并表明人种/种族存在一些差异。
Associations between ultraviolet radiation (UVR) exposure and non-Hodgkin lymphoma (NHL) have been inconsistent, but few studies have examined these associations for specific subtypes or across race/ethnicities. We evaluated the relationship between ambient UVR exposure and subtype-specific NHL incidence for whites, Hispanics, and blacks in the United States for years 2001–2010 (n=187,778 cases). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression. Incidence was lower for the highest UVR quintile for chronic/small lymphocytic/leukemia (CLL/SLL) (IRR= 0.87, 95% CI: 0.77–0.97), mantle cell (IRR= 0.82, 95% CI: 0.69, 0.97), lymphoplasmacytic (IRR= 0.58, 95% CI: 0.42–0.80), mucosa-associated lymphoid tissue (MZLMALT ) (IRR= 0.74, 95% CI: 0.60–0.90), follicular (FL) (IRR= 0.76, 95% CI: 0.68–0.86), diffuse large B-cell (IRR= 0.84, 95% CI: 0.76–0.94;), peripheral T-cell, other (PTCL) (IRR= 0.76, 95% CI: 0.61–0.95), and PTCL not otherwise specified (PNOS) (IRR= 0.77, 95% CI: 0.61–0.98). Trends were significant for MZLMALT, FL, DLBCL, BNOS and PTCL, with FL and DLBCL still significant after Bonferroni correction. We found interaction by race/ethnicity for CLL/SLL, FL, Burkitt, PNOS, and MF/SS, with CLL/SLL and FL still significant after Bonferroni correction. Some B-cell lymphomas (CLL/SLL, FL, Burkitt) suggested significant inverse relationships in whites and Hispanics, but not blacks. Some T-cell lymphomas suggested the most reduced risk for the highest quintile of UVR among blacks (PNOS and MF/SS), though trends were not significant. These findings strengthen the case for an inverse association of UVR exposure, support modest heterogeneity between NHL subtypes, and suggest some differences by race/ethnicity.
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DOI：
10.1016/j.jphotobiol.2010.08.001
发表时间：
2010-12-02
影响因子：
5.4
作者：
Freedman, D. Michal;Kimlin, Michael G.;Hoffbeck, Richard W.;Alexander, Bruce H.;Linet, Martha S.
通讯作者：
Linet, Martha S.
影响因子：
7.7
作者：
Boffetta, Paolo;van der Hel, Olga;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
20.3
作者：
Chang, Ellen T.;Canchola, Alison J.;Horn-Ross, Pamela L.
通讯作者：
Horn-Ross, Pamela L.
影响因子：
3.8
作者：
Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
7.1
作者：
Luczynska, Anna;Kaaks, Rudolf;Nieters, Alexandra
通讯作者：
Nieters, Alexandra