Multiple indicators of ambient and personal ultraviolet radiation exposure and risk of non-Hodgkin lymphoma (United States).
Multiple indicators of ambient and personal ultraviolet radiation exposure and risk of non-Hodgkin lymphoma (United States).
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DOI：
10.1016/j.jphotobiol.2010.08.001
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发表时间：
2010-12-02
影响因子：
5.4
通讯作者：
Linet, Martha S.
中科院分区：
文献类型：
--
作者：
Freedman, D. Michal;Kimlin, Michael G.;Hoffbeck, Richard W.;Alexander, Bruce H.;Linet, Martha S.
最近的流行病学研究表明，紫外线辐射(UV)可以预防非霍奇金淋巴瘤(NHL)，但很少有人(如果有的话)评估了环境和个人紫外线暴露的多种指标。利用美国放射技术学家的研究，我们检查了非霍奇金淋巴瘤与夏季自我报告的户外时间，以及基于不同年龄段卫星估计的全年和季节性平均环境暴露，以及回答了两份问卷(1994-1998年，2003-2005年)的参与者以及截至早期调查问卷未患癌症的参与者的日光敏感度之间的关系。使用非条件Logistic回归方法，我们估计了64,103名参与者137例非霍奇金淋巴瘤的优势比(OR)和95%可信区间。自我报告的夏季户外活动时间与风险无关。较低的风险在一定程度上与确诊前最接近时间段(20-39岁)的全年和冬季平均环境暴露水平较高有关。相对于全年平均环境紫外线最低四分位数的1.0，该年龄段依次较高四分位数的估计OR分别为0.68(0.42-1.10)、0.82(0.52-1.29)和0.64(0.40-1.03)，p趋势=0.06。较低的非霍奇金淋巴瘤风险与较高的全年平均水平和冬季环境紫外线相关联，为紫外线和非霍奇金淋巴瘤之间的保护性关系提供了适度的额外支持。
Recent epidemiologic studies have suggested that ultraviolet radiation (UV) may protect against non-Hodgkin lymphoma (NHL), but few, if any, have assessed multiple indicators of ambient and personal UV exposure. Using the U.S. Radiologic Technologists study, we examined the association between NHL and self-reported time outdoors in summer, as well as average year-round and seasonal ambient exposures based on satellite estimates for different age periods, and sun susceptibility in participants who had responded to two questionnaires (1994-1998, 2003-2005) and who were cancer-free as of the earlier questionnaire. Using unconditional logistic regression, we estimated the odds ratio (OR) and 95% confidence intervals for 64,103 participants with 137 NHL cases. Self-reported time outdoors in summer was unrelated to risk. Lower risk was somewhat related to higher average year-round and winter ambient exposure for the period closest in time, and prior to, diagnosis (ages 20-39). Relative to 1.0 for the lowest quartile of average year-round ambient UV, the estimated OR for successively higher quartiles was 0.68 (0.42-1.10); 0.82 (0.52-1.29); and 0.64(0.40-1.03), p-trend = 0.06), for this age period. The lower NHL risk associated with higher year-round average and winter ambient UV provides modest additional support for a protective relationship between UV and NHL.
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影响因子：
7.7
作者：
Boffetta, Paolo;van der Hel, Olga;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
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Freedman, DM;Zahm, SH;Dosemeci, M
通讯作者：
Dosemeci, M
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Chiu, Brian C. -H.
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通讯作者：
Seidler, Andreas
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作者：
Kelly, Jennifer L.;Friedberg, Jonathan W.;Fisher, Susan G.
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