Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.
Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.
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DOI：
10.1016/j.schres.2012.02.009
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发表时间：
2012-05
影响因子：
4.5
通讯作者：
Bassett, Anne S.
中科院分区：
文献类型：
--
作者：
Husted, Janice A.;Ahmed, Rashid;Chow, Eva W. C.;Brzustowicz, Linda M.;Bassett, Anne S.
关于家族性精神分裂症的环境因素的研究很少。我们在一个精神分裂症与NOSA1P基因相关的家族样本中调查了儿童期逆境或环境因素是否与精神分裂症相关。我们发现，包括儿童疾病，家庭不稳定性和大麻使用在内的累积逆境指数与狭义精神分裂症显著相关，独立于NOSA1P风险基因型，先前测量的儿童创伤，协变量和家族聚集性（调整后的比值比（95%置信区间）=1.55（1.01，2.38））。这些结果进一步支持了早期环境暴露影响精神分裂症的表达，即使在存在强烈的遗传易感性。
There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the NOSA1P gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of NOSA1P risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval)=1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.
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影响因子：
5.4
作者：
Schilling, Elizabeth A.;Aseltine, Robert H.;Gore, Susan
通讯作者：
Gore, Susan
影响因子：
4.5
作者：
Galletly, Cherrie;Van Hooff, Miranda;McFarlane, Alexander
通讯作者：
McFarlane, Alexander
影响因子：
5.6
作者：
Clark, Charlotte;Caldwell, Tanya;Stansfeld, Stephen A.
通讯作者：
Stansfeld, Stephen A.
影响因子：
64.8
作者：
van Os, Jim;Kenis, Gunter;Rutten, Bart P. F.
通讯作者：
Rutten, Bart P. F.
与NOS1AP基因相关的家族性精神分裂症的儿童创伤和遗传因素。
影响因子：
4.5
作者：
Husted, Janice A.;Ahmed, Rashid;Chow, Eva W. C.;Brzustowicz, Linda M.;Bassett, Anne S.
通讯作者：
Bassett, Anne S.