The application of conditioning paradigms in the measurement of pain.
The application of conditioning paradigms in the measurement of pain.
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DOI：
10.1016/j.ejphar.2013.03.002
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发表时间：
2013-09-15
影响因子：
5
通讯作者：
Li, Jun-Xu
中科院分区：
文献类型：
--
作者：
Li, Jun-Xu
疼痛是一种涉及感官和情感成分的私人体验。动物对疼痛的研究只能通过它们的反应来推断，因此，反射反应的测量在近一个世纪的疼痛文献中占据主导地位。有人认为，尽管反射反应对于揭示生物体疼痛的感觉本质很重要，但疼痛影响同样重要，但由于缺乏有效的动物模型，在疼痛研究中很大程度上被忽略了。开始理解疼痛影响的一个策略是使用条件反射原理来间接揭示疼痛的情感状况。这篇综述批判性地分析了几种被认为可以测量疼痛情感学习的方法。讨论了目前疼痛研究的相关知识、应用及其优缺点。我们建议，在未来的疼痛研究中，这些方法应与传统的基于反射的疼痛测量相结合，这将极大地有利于理解疼痛的神经基础和新型镇痛药的临床前评估。
Pain is a private experience that involves both sensory and emotional components. Animal studies of pain can only be inferred by their responses, and therefore the measurement of reflexive responses dominate the pain literature for nearly a century. It has been argued that although reflexive responses are important to unveil the sensory nature of pain in organisms, pain affect is equally important but largely ignored in pain studies primarily due to the lack of validated animal models. One strategy to begin to understand pain affect is to use conditioning principles to indirectly reveal the affective condition of pain. This review critically analyzed several procedures that are thought to measure affective learning of pain. The procedures regarding the current knowledge, the applications, and their advantages and disadvantages in pain research are discussed. It is proposed that these procedures should be combined with traditional reflex-based pain measurements in future studies of pain, which could greatly benefit both the understanding of neural underpinnings of pain and preclinical assessment of novel analgesics.
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