Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.
Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.
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DOI：
10.1016/j.neuropharm.2016.03.049
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发表时间：
2016-09
影响因子：
4.7
通讯作者：
Mateo Y
中科院分区：
文献类型：
--
作者：
Salinas AG;Davis MI;Lovinger DM;Mateo Y
纹状体通常根据其主要的输出通路进行分类，这些通路由多巴胺D1和D2受体表达的神经元组成。根据许多蛋白质的差异表达，纹状体也被分为纹状体和基质小室，包括u阿片受体、多巴胺转运体(DAT)和Nr4a1(核受体亚家族4，A组，成员1)。纹状体和基质之间的许多功能差异与多巴胺相关的神经疾病有关，包括帕金森氏症和成瘾。使用Nr4a1-EGFP小鼠，我们提供了证据表明，电诱发的多巴胺释放在纹状体和基质之间以一种区域不同的方式不同。我们进一步证明，这种差异并不是由于多巴胺自身受体或烟碱型乙酰胆碱受体对多巴胺释放抑制的差异。此外，可卡因对纹状体细胞外多巴胺的促进作用大于对基质的作用，同时对基质中的多巴胺摄取的抑制作用大于对纹状体的抑制作用。重要的是，可卡因敏感性的这些区段差异仅限于背侧纹状体。这些发现证明了DAT对纹状体中相对于基质的多巴胺的精细微解剖调节水平。
The striatum is typically classified according to its major output pathways, which consist of dopamine D1 and D2 receptor-expressing neurons. The striatum is also divided into striosome and matrix compartments, based on the differential expression of a number of proteins, including the mu opioid receptor, dopamine transporter (DAT), and Nr4a1 (nuclear receptor subfamily 4, group A, member 1). Numerous functional differences between the striosome and matrix compartments are implicated in dopamine-related neurological disorders including Parkinson’s disease and addiction. Using Nr4a1-eGFP mice, we provide evidence that electrically evoked dopamine release differs between the striosome and matrix compartments in a regionally-distinct manner. We further demonstrate that this difference is not due to differences in inhibition of dopamine release by dopamine autoreceptors or nicotinic acetylcholine receptors. Furthermore, cocaine enhanced extracellular dopamine in striosomes to a greater degree than in the matrix and concomitantly inhibited dopamine uptake in the matrix to a greater degree than in striosomes. Importantly, these compartment differences in cocaine sensitivity were limited to the dorsal striatum. These findings demonstrate a level of exquisite microanatomical regulation of dopamine by the DAT in striosomes relative to the matrix.
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影响因子：
2.9
作者：
Crittenden JR;Graybiel AM
通讯作者：
Graybiel AM
DOI：
10.1111/ejn.12426
发表时间：
2014-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Crowley NA;Cody PA;Davis MI;Lovinger DM;Mateo Y
通讯作者：
Mateo Y
影响因子：
25
作者：
Canales, JJ;Graybiel, AM
通讯作者：
Graybiel, AM
伏隔核中GABA能中型棘神经元的分布和分室组织。
影响因子：
3.5
作者：
Gangarossa G;Espallergues J;de Kerchove d'Exaerde A;El Mestikawy S;Gerfen CR;Hervé D;Girault JA;Valjent E
通讯作者：
Valjent E
影响因子：
56.9
作者：
GERFEN, CR;ENGBER, TM;SIBLEY, DR
通讯作者：
SIBLEY, DR