Antidiabetic Function of Lactobacillus fermentum MF423-Fermented Rice Bran and Its Effect on Gut Microbiota Structure in Type 2 Diabetic Mice.
Antidiabetic Function of Lactobacillus fermentum MF423-Fermented Rice Bran and Its Effect on Gut Microbiota Structure in Type 2 Diabetic Mice.
复制标题
发酵乳杆菌MF423发酵米糠的抗糖尿病功能及其对2型糖尿病小鼠肠道菌群结构的影响
DOI：
10.3389/fmicb.2021.682290
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发表时间：
2021
影响因子：
5.2
通讯作者：
He H
中科院分区：
文献类型：
--
作者：
Ai X;Wu C;Yin T;Zhur O;Liu C;Yan X;Yi C;Liu D;Xiao L;Li W;Xie B;He H
米糠是一种工业副产品，尽管其生物利用度有限，但具有多种生物活性。本研究以米糠为原料，经发酵乳杆菌MF423（FLRB）发酵后，在体内外均具有较好的抗糖尿病作用。FLRB可增加胰岛素抵抗HepG2细胞的葡萄糖消耗，减少脂质蓄积。FLRB治疗8周可显著降低2型糖尿病（T2DM）小鼠的血糖和血脂水平，并提高抗氧化活性。H&E染色显示FLRB处理的小鼠的肝脏中的明显病变减轻。此外，高通量测序显示FLRB治疗小鼠的肠道微生物群组成存在显着变化，特别是对于短链脂肪酸（SCFA）生产细菌，如Dubosiella和Lactobacillus。综上所述，我们的研究结果表明，米糠发酵产物可以调节肠道菌群，改善T2DM相关的生化异常，因此它们可以作为潜在的益生菌或膳食补充剂。
Rice bran is an industrial byproduct that exerts several bioactivities despite its limited bioavailability. In this study, rice bran fermented with Lactobacillus fermentum MF423 (FLRB) had enhanced antidiabetic effects both in vitro and in vivo. FLRB could increase glucose consumption and decrease lipid accumulation in insulin resistant HepG2 cells. Eight weeks of FLRB treatment significantly reduced the levels of blood glucose and lipids and elevated antioxidant activity in type 2 diabetic mellitus (T2DM) mice. H&E staining revealed alleviation of overt lesions in the livers of FLRB-treated mice. Moreover, high-throughput sequencing showed notable variation in the composition of gut microbiota in FLRB-treated mice, especially for short-chain fatty acids (SCFAs)-producing bacteria such as Dubosiella and Lactobacillus. In conclusion, our results suggested that rice bran fermentation products can modulate the intestinal microbiota and improve T2DM-related biochemical abnormalities, so they can be applied as potential probiotics or dietary supplements.
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影响因子：
6.1
作者：
Liu, Suwen;Chang, Xuedong;Xu, Weifeng
通讯作者：
Xu, Weifeng
影响因子：
6.1
作者：
Chen, Li-Chun;Fan, Zhong-Yang;Zhang, Shi-Yu
通讯作者：
Zhang, Shi-Yu
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
24.5
作者：
Anhe, Fernando F.;Roy, Denis;Marette, Andre
通讯作者：
Marette, Andre
影响因子：
5.2
作者：
Chen, Yung-Tsung;Lin, Yu-Chun;Chen, Ming-Ju
通讯作者：
Chen, Ming-Ju