Pathological resting-state executive and language system perfusion in first-episode psychosis.
Pathological resting-state executive and language system perfusion in first-episode psychosis.
复制标题
DOI：
10.1016/j.nicl.2022.103261
复制
发表时间：
2022
影响因子：
4.2
通讯作者：
Coffman, Brian A.
中科院分区：
文献类型：
--
作者：
Salisbury, Dean F.;Curtis, Mark;Longenecker, Julia;Yeh, Fang-Cheng;Kim, Tae;Coffman, Brian A.
在首发精神病中，多个语言相关区域的基线静息脑灌注升高，表明语言和语义相关区域过度活动。首发精神病中几个执行控制区的基线静息灌注减少，表明高阶认知控制区活动不足。幻觉者和非幻觉者之间首发精神病的基础灌注差异没有显着差异，表明这些模式与新出现的精神病广泛相关。皮质（例如布罗卡区和韦尼克区）和皮质下（例如壳核）语言相关区域和执行控制区域（例如额下回（IFG）、背外侧前额皮质（DLPFC））在长期精神病中表现出功能和结构脱节。我们检查了静息态基础灌注水平是否揭示了首发精神病（FEP）中语言相关和执行区域的选择性病理生理学（可能是低激活和过度激活）。使用伪连续动脉旋转标记（pcASL）测量基础静息态灌注。对 32 名 FEP 和 34 名匹配的健康对照 (HC) 个体之间的相对脑血流量 (rCBF) 进行了比较。在同一疗程中使用 3T Prisma 扫描仪获取结构和功能 MRI 扫描。静息 rCBF 的全脑比较发现了 8 个具有显着组间差异的簇。在左、右 IFG、右 DLPFC 和右顶叶皮层的执行控制区发现 rCBF 减少。在左右颞叶皮层（包括韦尼克区）以及左右壳核中发现 rCBF 增加。幻听严重程度与左壳核 rCBF 呈正相关。在灌注意味着激活的情况下，双侧颞叶和壳核的语言和听觉处理区域表现出病理性过度活跃，而认知控制区域（IFG、DLPFC、右顶叶）在休息时的 FEP 中表现出病理性低活跃。病理基础活动存在于整个症状严重程度范围内，表明这可能是精神病的常见基础病理学，可以通过非侵入性脑刺激来使静息活动水平正常化。
Baseline resting brain perfusion was elevated in several language-related areas in first episode psychosis, indicating over-activity in language and semantic related areas. Baseline resting perfusion was reduced in several executive control regions in first episode psychosis, indicating underactivity of higher-order cognitive control areas. Basal perfusion differences in first episode psychosis were not markedly different between hallucinators and non-hallucinators, suggesting these patterns were associated broadly with emerging psychosis. Cortical (e.g., Broca’s area and Wernicke’s area) and subcortical (e.g., putamen) language-related areas and executive control areas (e.g., inferior frontal gyrus (IFG), dorsolateral prefrontal cortex (DLPFC)) show functional and structural dysconnectivity in long-term psychosis. We examined whether resting-state basal perfusion levels revealed selective pathophysiology (likely hypo- and hyper-activation) of language-related and executive areas in first-episode psychosis (FEP). Basal resting-state perfusion was measured using pseudo-continuous Arterial Spin Labeling (pcASL). Relative cerebral blood flow (rCBF) was compared between 32 FEP and 34 matched healthy comparison (HC) individuals. Structural and functional MRI scans were acquired using a 3T Prisma scanner during the same session. Whole-brain comparison of resting rCBF identified 8 clusters with significant between-group differences. Reduced rCBF was found in executive control areas in left and right IFG, right DLPFC, and right parietal cortex. Increased rCBF was found in left and right temporal cortex (including Wernicke’s area), and left and right putamen. A positive correlation was observed between auditory hallucination severity and rCBF in the left putamen. To the degree that perfusion implies activation, language and auditory processing areas in bilateral temporal lobe and putamen showed pathological hyper-activity, and cognitive control areas (IFG, DLPFC, right parietal) showed pathological hypo-activity in FEP at rest. Pathological basal activity was present across the range of symptom severity, suggesting it may be a common underlying pathology for psychosis that may be targeted with non-invasive brain stimulation to normalize resting activity levels.
登录
查看更多内容
影响因子：
2.3
作者：
Lennox, BR;Park, SBG;Jones, PB
通讯作者：
Jones, PB
影响因子：
11.3
作者：
McCarthy-Jones, Simon;Smailes, David;Dudley, Robert
通讯作者：
Dudley, Robert
影响因子：
2.5
作者：
Wang, Ze;Aguirre, Geoffrey K.;Detre, John A.
通讯作者：
Detre, John A.
影响因子：
17.7
作者：
Barch, Deanna M.;Csernansky, John G.
通讯作者：
Csernansky, John G.
影响因子：
3.7
作者：
Hoffman, Ralph E.;Hampson, Michelle;Krystal, John H.
通讯作者：
Krystal, John H.