Congenital deafness affects deep layers in primary and secondary auditory cortex.
Congenital deafness affects deep layers in primary and secondary auditory cortex.
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DOI：
10.1002/cne.24267
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发表时间：
2017-10-01
期刊：
影响因子：
--
通讯作者：
Kral A
中科院分区：
文献类型：
--
作者：
Berger C;Kühne D;Scheper V;Kral A
先天性耳聋导致听觉皮层功能缺陷，早期人工耳蜗植入可以有效弥补。这些缺陷中的大多数已被证明是功能性的。此外，大多数先前关于耳聋的研究都涉及初级听觉皮层;对高阶区域的了解仅限于跨模态重组的影响。在这项研究中，我们比较了成年听力和先天性耳聋猫（CDC）的四个皮质区的皮质细胞结构：初级听觉场A1，两个次级听觉场，即背区和第二听觉场（A2）;以及使用Nissl或SMI-32抗体染色的同一切片中的参考视觉关联场（7区）。在先天性耳聋动物中，听觉皮层的一般细胞结构模式和区域特异性特征保持不变。而区域7没有不同的组之间的调查，所有的听觉领域略薄的CDC，这是由于减少厚度的第四层-第六层。该研究证明，虽然细胞结构模式通常独立于感觉体验，但在IV层和颗粒下层的初级和高阶听觉场中观察到层厚度减少。这项研究表明，先天性耳聋的影响上颗粒和其他皮质层之间的差异，但类似的营养不良的影响，在所有调查的听觉领域。
Congenital deafness leads to functional deficits in the auditory cortex for which early cochlear implantation can effectively compensate. Most of these deficits have been demonstrated functionally. Furthermore, the majority of previous studies on deafness have involved the primary auditory cortex; knowledge of higher‐order areas is limited to effects of cross‐modal reorganization. In this study, we compared the cortical cytoarchitecture of four cortical areas in adult hearing and congenitally deaf cats (CDCs): the primary auditory field A1, two secondary auditory fields, namely the dorsal zone and second auditory field (A2); and a reference visual association field (area 7) in the same section stained either using Nissl or SMI‐32 antibodies. The general cytoarchitectonic pattern and the area‐specific characteristics in the auditory cortex remained unchanged in animals with congenital deafness. Whereas area 7 did not differ between the groups investigated, all auditory fields were slightly thinner in CDCs, this being caused by reduced thickness of layers IV–VI. The study documents that, while the cytoarchitectonic patterns are in general independent of sensory experience, reduced layer thickness is observed in both primary and higher‐order auditory fields in layer IV and infragranular layers. The study demonstrates differences in effects of congenital deafness between supragranular and other cortical layers, but similar dystrophic effects in all investigated auditory fields.
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影响因子：
2.5
作者：
Butler, Blake E.;Chabot, Nicole;Lomber, Stephen G.
通讯作者：
Lomber, Stephen G.
影响因子：
2.8
作者：
Fallon, James B.;Shepherd, Robert K.;Irvine, Dexter R. F.
通讯作者：
Irvine, Dexter R. F.
影响因子：
2.5
作者：
Beitel, Ralph E.;Vollmer, Maike;Schreiner, Christoph E.
通讯作者：
Schreiner, Christoph E.
DOI：
10.1126/science.1236425
发表时间：
2013-06-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinople CM;Bruno RM
通讯作者：
Bruno RM
影响因子：
25
作者：
Bajo VM;Nodal FR;Moore DR;King AJ
通讯作者：
King AJ