Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.
Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.
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DOI：
10.1016/j.exger.2021.111669
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发表时间：
2022-03
影响因子：
3.9
通讯作者：
Schneider A
中科院分区：
文献类型：
--
作者：
Isola JVV;Zanini BM;Hense JD;Alvarado-Rincón JA;Garcia DN;Pereira GC;Vieira AD;Oliveira TL;Collares T;Gasperin BG;Stout MB;Schneider A
热量限制（CR）（25-40%）是最常研究的减少年龄相关疾病的策略，也被发现可以延长雌性小鼠的生殖寿命。然而，轻度CR（10%），这是可持续的，对卵巢衰老的影响尚未得到解决。17α-雌二醇（17α-E2）是另一种干预措施，可积极调节小鼠的健康寿命和寿命，但其对雌性生殖的影响尚不清楚。我们评估了24周内轻度CR（10%）和17α-E2治疗对卵巢储备和女性生育力的影响，并将这些影响与更常用的30%CR方案进行了比较。10%和30%CR对卵巢储备功能的保护都有积极作用，而17α-E2对卵巢功能相关参数无影响。在重新喂养后，10%和30%的生育率都增加了，这可以通过更高的怀孕率来证明。与卵巢储备数据一致，17α-E2也未能改善生育能力。总的来说，这些数据表明，10% CR可有效保护卵巢功能和生育能力，而17α-E2似乎不具有延缓卵巢衰老的治疗潜力。
Calorie restriction (CR) (25–40%) is the most commonly studied strategy for curtailing age-related disease and has also been found to extend reproductive lifespan in female mice. However, the effects of mild CR (10%), which is sustainable, on ovarian aging has not yet been addressed. 17α-estradiol (17α-E2) is another intervention shown to positively modulate healthspan and lifespan in mice but its effects on female reproduction remain unclear. We evaluated the effects of mild CR (10%) and 17α-E2 treatment on ovarian reserve and female fertility over a 24-week period, and compared these effects with the more commonly employed 30% CR regimen. Both 10% and 30% CR elicited positive effects on the preservation of ovarian reserve, whereas 17α-E2 did not alter parameters associated with ovarian function. Following refeeding, both 10% and 30% increased fertility as evidenced by greater pregnancy rates. In aligned with the ovarian reserve data, 17α-E2 also failed to improve fertility. Collectively, these data indicate that 10% CR is effective in preserving ovarian function and fertility, while 17α-E2 does not appear to have therapeutic potential for delaying ovarian aging.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
归因于17α-雌二醇（一种延伸寿命的化合物）归因于雌激素受体α介导的。
影响因子：
7.7
作者：
Mann SN;Hadad N;Nelson Holte M;Rothman AR;Sathiaseelan R;Ali Mondal S;Agbaga MP;Unnikrishnan A;Subramaniam M;Hawse J;Huffman DM;Freeman WM;Stout MB
通讯作者：
Stout MB
影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L