The Global Enteric Multicenter Study (GEMS): impetus, rationale, and genesis.
The Global Enteric Multicenter Study (GEMS): impetus, rationale, and genesis.
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DOI：
10.1093/cid/cis761
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Muhsen K
中科院分区：
文献类型：
--
作者：
Levine MM;Kotloff KL;Nataro JP;Muhsen K
腹泻病仍然是发展中国家幼儿死亡的两大原因之一。虽然水/卫生基础设施和个人卫生的改善可以减少肠道病原体的传播，但疫苗也可以加速腹泻病发病率和死亡率的下降。从1980年到大约2004年，进行了各种病例/对照和小型队列研究，以解决发展中国家儿童腹泻的病因。许多研究存在方法上的局限性，得出了不同的结论，因此很难确定不同病原体的相对重要性。因此，在新千年的头几年，对于应当开发或实施何种疟疾疫苗没有达成共识;但是，人们一致认为，需要进行精心设计的研究，以获得关于更严重形式的疟疾的病因和负担的信息，从而指导全球投资和实施决定。因此，全球肠道多中心研究（GEMS）的目的是克服早期研究的缺点，并确定儿科肠道疾病的病因和基于人群的负担。GEMS，其中包括有史以来最大的传染病综合征病例/对照研究之一在撒哈拉以南非洲的4个地点推出了一项新的全球艾滋病毒/艾滋病方案（目标是约12600例可分析病例和12600例对照病例），（冈比亚、肯尼亚、马里、莫桑比克）和南亚3个（孟加拉国、印度、巴基斯坦），每个地点都与人口监测下的人口相联系（5岁以下儿童的观察总数约为467 000儿童年）。GEMS数据将指导投资，并帮助优先考虑降低儿科腹泻病发病率和死亡率的战略。
Diarrheal disease remains one of the top 2 causes of young child mortality in the developing world. Whereas improvements in water/sanitation infrastructure and hygiene can diminish transmission of enteric pathogens, vaccines can also hasten the decline of diarrheal disease morbidity and mortality. From 1980 through approximately 2004, various case/control and small cohort studies were undertaken to address the etiology of pediatric diarrhea in developing countries. Many studies had methodological limitations and came to divergent conclusions, making it difficult to prioritize the relative importance of different pathogens. Consequently, in the first years of the millennium there was no consensus on what diarrheal disease vaccines should be developed or implemented; however, there was consensus on the need for a well-designed study to obtain information on the etiology and burden of more severe forms of diarrheal disease to guide global investment and implementation decisions. Accordingly, the Global Enteric Multicenter Study (GEMS) was designed to overcome drawbacks of earlier studies and determine the etiology and population-based burden of pediatric diarrheal disease. GEMS, which includes one of the largest case/control studies of an infectious disease syndrome ever undertaken (target approximately 12 600 analyzable cases and 12 600 controls), was rolled out in 4 sites in sub-Saharan Africa (Gambia, Kenya, Mali, Mozambique) and 3 in South Asia (Bangladesh, India, Pakistan), with each site linked to a population under demographic surveillance (total approximately 467 000 child years of observation among children <5 years of age). GEMS data will guide investment and help prioritize strategies to mitigate the morbidity and mortality of pediatric diarrheal disease.
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影响因子：
--
作者：
ALBWARDY, MAA;RAMIA, S;SALMAN, H
通讯作者：
SALMAN, H
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
6.4
作者：
BAQUI, AH;SACK, RB;SIDDIQUE, AK
通讯作者：
SIDDIQUE, AK
DOI：
10.2471/blt.07.050054
发表时间：
2008-09-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Boschi-Pinto, Cynthia;Velebit, Lana;Shibuya, Kenji
通讯作者：
Shibuya, Kenji
DOI：
10.4269/ajtmh.2010.10-0367
发表时间：
2010-11-01
影响因子：
3.3
作者：
Bodhidatta, Ladaporn;McDaniel, Philip;Mason, Carl J.
通讯作者：
Mason, Carl J.