Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing
Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing
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基于离子纳米储库的双网络水凝胶用于胃穿孔密封
DOI：
10.1007/s40843-021-1849-3
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Gu Ning
中科院分区：
文献类型：
--
作者：
Yuan Yuehui;Wu Hao;Ren Xueyang;Wang Jianwu;Liu Ruiqing;Hu Benhui;Gu Ning
近年来，用于体内组织愈合的可注射水凝胶研究取得了显著进展。然而，由于胃酸酸性强且胃壁会剧烈变形，水凝胶用于治疗胃穿孔时，治疗效果通常有限。针对这些挑战，我们提出了一种基于离子纳米储库（INR）的双网络水凝胶，其具有出色的粘附性和力学性能，能够轻松应用于穿孔部位，在封堵穿孔的同时促进组织修复。结果表明，由聚丙烯酰胺构成的第一网络在蓝光照射下5秒内即可在胃组织上交联，并通过机械互锁增强粘附性能。纳米羟基磷灰石作为离子纳米储库，在酸性环境下可逐渐释放Ca²⁺，与海藻酸钠形成第二网络，抑制水凝胶在胃液中的溶胀。同时，在1 - 乙基 - 3 -（3 - 二甲基氨基丙基）碳二亚胺/ N - 羟基琥珀酰亚胺（EDC / NHS）存在的情况下，通过水凝胶 - 组织界面处的酰胺共价键进一步增强粘附力。通过INR策略获得的双网络水凝胶有望成为治疗胃穿孔及其他类似生物医学问题的潜在方案。
In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of gastric perforation due to the high acidic gastric juice and violent deformation of the gastric wall.Regarding these challenges,we proposed an ionic nano-reservoir (INR)-based dual-network hydrogel,which has excellent adhesion and mechanical properties,and can be easily applied to the perforation site to block the perforation while promoting tissue repairing.The results showed that the first network made of polyacrylamide had cross-linked on the stomach tissue within 5 s under blue light,and enhanced the adhesion performance through mechanical interlock.The nano-hydroxyapatite acted as ionic INR,which can gradually release Ca~(2+) under acid environments to form the second network with sodium alginate and inhibit the swelling of hydrogel in gastric juice.Meanwhile,the adhesion was further enhanced through amide covalent bonds at the hydrogel-tissue interface with the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide (EDC/NHS).The dual network hydrogels obtained by the INR strategy could be employed as a potential therapeutic option for gastric perforation and other similar biomedical prolems.
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