Bio-inspired hydrogel-based bandage with robust adhesive and antibacterial abilities for skin closure.
Bio-inspired hydrogel-based bandage with robust adhesive and antibacterial abilities for skin closure.
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仿生水凝胶绷带具有强大的粘合力和抗菌能力，可闭合皮肤
DOI：
10.1007/s40843-021-1724-8
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Chi B
中科院分区：
文献类型：
--
作者：
Wang P;Pu Y;Ren Y;Liu S;Yang R;Tan X;Zhang W;Shi T;Li S;Chi B
虽然传统的缝合技术通常用于辅助伤口闭合，但它们的作用有限，并可能导致伤口组织的二次损伤。受海洋生物贻贝的启发，我们设计并制造了一种具有坚韧湿组织粘附力的生物灵感水凝胶绷带，以替代传统的手术缝合线，加速伤口愈合并避免感染。采用3，4-二羟基苯丙氨酸和甲基丙烯酸缩水甘油酯对聚γ-谷氨酸进行改性，并将其引入到丙烯酸-丙烯酰胺共聚物水凝胶基质中，制备了力学性能稳定的水凝胶。水凝胶绷带显示出强的化学键合粘附（70 ± 2.1 kPa），是商业组织粘合剂纤维蛋白胶（25 ± 2.2 kPa）的2.8倍。该水凝胶绷带不仅能保持自稳定性，还能在14-70 kPa范围内自调节粘合强度，通过调节组分比例达到不同的粘合效果。该绷带具有理想的压缩性能（0.7 ± 0.11 MPa）和拉伸伸长率（约25倍），这确保了其抗损伤性，特别是在关节间隙中。其次，绷带的邻苯二酚结构赋予其抗氧化和内源性广谱抗菌性能。结果还显示了优异的细胞相容性和血液相容性，证明了其合格的生物安全性。在大鼠全层皮肤缺损模型中，我们可以清楚地观察到绷带具有促进伤口愈合的能力（仅需6天）。本研究为灾害救援中肝脏止血和心肌修复的应急处理提供了新的策略。 实验详情和支持数据可参见论文10.1007/s40843-021-1724-8的在线版本。
Although conventional suturing techniques are commonly used in assisting wound closure, they do pose limited conduciveness and may lead to secondary injury to wound tissues. Inspired by marine organism mussels, we designed and manufactured a bio-inspired hydrogel-based bandage with tough wet tissue adhesion to substitute traditional surgical suture, accelerate wound healing and avoid infection. Poly(γ-glutamic acid) was modified with 3,4-dihydroxyphenylalanine and glycidyl methacylate, then introduced into the acrylic acid-co-acrylamide hydrogel matrix with robust mechanical properties. The hydrogel bandage showed strong chemical linkage adhesion (70 ± 2.1 kPa), which is 2.8 times that of commercial tissue adhesive fibrin glue (25 ± 2.2 kPa). The hydrogel bandage can not only maintain the self-stability, but is also capable of self-tuning adhesive strength in the range of 14–70 kPa to achieve different adhesion effects by tuning constituent ratio. The bandage has desirable compression properties (0.7 ± 0.11 MPa) and tensile elongation (about 25 times), which ensures its resistance to damages, especially in joint spaces. Secondly, the bandage was endowed with antioxidant and endogenous broad-spectrum antibacterial properties with its catechol structure. Results also demonstrated excellent cell compatibility and blood compatibility, certifying its eligible biological safety profile. In a rat full-thickness cutaneous deficiency model, we can clearly observe that the bandage possesses the ability to promote wound healing (only need 6 days). Above all, this research provides a new strategy for the emergency treatment of liver hemostasis and myocardial repair during disaster rescue. Experimental details and supporting data are available in the online version of the paper10.1007/s40843-021-1724-8.
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