Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults.
Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults.
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DOI：
10.3390/nu16010151
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发表时间：
2024-01-02
期刊：
影响因子：
5.9
通讯作者：
Stanhope KL
中科院分区：
文献类型：
--
作者：
Hieronimus B;Medici V;Lee V;Nunez MV;Sigala DM;Bremer AA;Cox CL;Keim NL;Schwarz JM;Pacini G;Tura A;Havel PJ;Stanhope KL
(1)背景：过量糖摄入对胰岛素敏感性影响的临床结果相互矛盾，可能与糖型和胰岛素敏感性指数（ISI）评估的差异有关。因此，我们比较了摄入四种不同糖对口服葡萄糖耐量试验（OGTT）得出的胰岛素敏感性指标的影响。(2)方法：年轻人饮用含果糖、葡萄糖、高果糖玉米糖浆、蔗糖或阿斯巴甜的饮料（SB） 2周。参与者在干预之前和结束时接受OGTT。评估空腹血糖和胰岛素、稳态模型评估-胰岛素抵抗（HOMA-IR）、血糖和胰岛素曲线下面积、代肝脏胰岛素抵抗指数、Matsuda ISI、predict M ISI和Stumvoll指数。对结果进行分析，以确定：(1)5种SB的作用；(3)结果：果糖-SB和混合糖中的果糖成分对评估肝脏胰岛素敏感性的结果有负面影响，而葡萄糖没有。葡萄糖- sb和混合糖中的葡萄糖组分对肌肉胰岛素敏感性的影响比果糖更负。(4)结论：摄入糖- sb对胰岛素敏感性的影响随糖的种类和ISI指数的不同而不同，因为肝脏胰岛素敏感性的评估结果受果糖的负面影响，而肌肉胰岛素敏感性的评估结果受葡萄糖的负面影响更大。
(1) Background: Clinical results on the effects of excess sugar consumption on insulin sensitivity are conflicting, possibly due to differences in sugar type and the insulin sensitivity index (ISI) assessed. Therefore, we compared the effects of consuming four different sugars on insulin sensitivity indices derived from oral glucose tolerance tests (OGTT). (2) Methods: Young adults consumed fructose-, glucose-, high-fructose corn syrup (HFCS)-, sucrose-, or aspartame-sweetened beverages (SB) for 2 weeks. Participants underwent OGTT before and at the end of the intervention. Fasting glucose and insulin, Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), glucose and insulin area under the curve, Surrogate Hepatic Insulin Resistance Index, Matsuda ISI, Predicted M ISI, and Stumvoll Index were assessed. Outcomes were analyzed to determine: (1) effects of the five SB; (2) effects of the proportions of fructose and glucose in all SB. (3) Results: Fructose-SB and the fructose component in mixed sugars negatively affected outcomes that assess hepatic insulin sensitivity, while glucose did not. The effects of glucose-SB and the glucose component in mixed sugar on muscle insulin sensitivity were more negative than those of fructose. (4) Conclusion: the effects of consuming sugar-SB on insulin sensitivity varied depending on type of sugar and ISI index because outcomes assessing hepatic insulin sensitivity were negatively affected by fructose, and outcomes assessing muscle insulin sensitivity were more negatively affected by glucose.
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影响因子：
29.4
作者：
Schwarz JM;Noworolski SM;Erkin-Cakmak A;Korn NJ;Wen MJ;Tai VW;Jones GM;Palii SP;Velasco-Alin M;Pan K;Patterson BW;Gugliucci A;Lustig RH;Mulligan K
通讯作者：
Mulligan K
在临床和研究环境中测量和估计胰岛素抵抗。
DOI：
10.1002/oby.23503
发表时间：
2022-08
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.metabol.2020.154356
发表时间：
2020-11
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Hieronimus B;Medici V;Bremer AA;Lee V;Nunez MV;Sigala DM;Keim NL;Havel PJ;Stanhope KL
通讯作者：
Stanhope KL
DOI：
10.1210/clinem/dgab508
发表时间：
2021-10-21
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Sigala DM;Hieronimus B;Medici V;Lee V;Nunez MV;Bremer AA;Cox CL;Price CA;Benyam Y;Chaudhari AJ;Abdelhafez Y;McGahan JP;Goran MI;Sirlin CB;Pacini G;Tura A;Keim NL;Havel PJ;Stanhope KL
通讯作者：
Stanhope KL
影响因子：
5.8
作者：
Schwarz, Jean-Marc;Noworolski, Susan M.;Mulligan, Kathleen
通讯作者：
Mulligan, Kathleen