An estimation of the absolute number of axons indicates that human cortical areas are sparsely connected.
An estimation of the absolute number of axons indicates that human cortical areas are sparsely connected.
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DOI：
10.1371/journal.pbio.3001575
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发表时间：
2022-03
期刊：
影响因子：
9.8
通讯作者：
Halgren E
中科院分区：
文献类型：
--
作者：
Rosen BQ;Halgren E
皮质区域之间的束被认为在皮质信息处理中发挥着核心作用，但它们在人类中的实际数量从未确定。在这里，我们从全皮质扩散 MRI (dMRI) 连接组中估计了连接皮质区域的轴突的绝对数量，并使用组织学测量的胼胝体纤维密度进行了校准。据估计，半球内皮质区域之间的中位连接大约有 6,200 个轴突，半球之间大约有 1,300 个轴突，连接功能相关区域的轴突极其稀疏。例如，我们估计弓状束和上纵束干中 <5% 的轴突连接韦尼克区和布罗卡区。这些结果表明，详细信息在皮质区域之间传输，要么通过密集的局部连接，要么通过罕见的、极其特权的远程连接。使用人类连接组计划的数据来估计连接皮质区域的轴突的绝对数量，得出了令人惊讶的稀疏连接性；协调大规模的功能同步与稀疏的解剖连接对我们目前对人类大脑组织的理解提出了挑战。
The tracts between cortical areas are conceived as playing a central role in cortical information processing, but their actual numbers have never been determined in humans. Here, we estimate the absolute number of axons linking cortical areas from a whole-cortex diffusion MRI (dMRI) connectome, calibrated using the histologically measured callosal fiber density. Median connectivity is estimated as approximately 6,200 axons between cortical areas within hemisphere and approximately 1,300 axons interhemispherically, with axons connecting functionally related areas surprisingly sparse. For example, we estimate that <5% of the axons in the trunk of the arcuate and superior longitudinal fasciculi connect Wernicke’s and Broca’s areas. These results suggest that detailed information is transmitted between cortical areas either via linkage of the dense local connections or via rare, extraordinarily privileged long-range connections. Using data from Human Connectome Project to estimate the absolute number of axons linking cortical areas yields surprisingly sparse connectivity; reconciling large-scale functional synchronization with sparse anatomical connectivity presents a challenge for our present understanding of human brain organization.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
2.4
作者：
Barbas H;Hilgetag CC;Saha S;Dermon CR;Suski JL
通讯作者：
Suski JL
影响因子：
4.6
作者：
Beul SF;Barbas H;Hilgetag CC
通讯作者：
Hilgetag CC
影响因子：
10.6
作者：
Highley, JR;Esiri, MM;Crow, TJ
通讯作者：
Crow, TJ
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana