Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes.
Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes.
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DOI：
10.1016/j.pscychresns.2011.01.005
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发表时间：
2011-07-30
影响因子：
11.3
通讯作者：
Sweeney JA
中科院分区：
文献类型：
--
作者：
Pavuluri MN;Passarotti AM;Lu LH;Carbray JA;Sweeney JA
目的：探讨利培酮与异丙丙胺对儿童躁狂症脑功能的相对影响。这是一项为期6周的双盲fMRI试验，24名未服药的躁狂症患者被随机分为利培酮或异丙戊组，14名健康对照(HC)在智商和人口学因素上匹配(平均年龄：13.1±3.3岁)。在儿童情感配色任务中，受试者将一个积极、消极或中性的单词的颜色与两个彩色圆圈中的一个进行匹配。主要临床测量为青年躁狂评定量表(YMRS)。利培酮组在负性状态时，右侧扣带回前部和膝下部皮质的激活较治疗前和治疗后增加，双侧额中回的激活减少，阳性状态下的左侧下部、内侧、右侧额中回、左侧顶叶下部和右侧纹状体的激活减少。与HC组相比，异丙孕组负性状态下右侧颞上回激活增强，阳性状态下左侧额叶内侧回和右侧楔前回激活增强。利培酮组治疗前右侧杏仁核活动呈阴性或阳性，异丙丙酮组左侧杏仁核活动呈阳性，预示YMRS反应差。在儿童躁狂症的情绪处理任务中，利培酮和异丙丙胺产生不同的前额叶活动模式。基线时杏仁核活动增加是一个潜在的生物标志物，预测利培酮和异丙戊酸治疗反应差。
To determine the relative effects of risperidone and divalproex on brain function in pediatric mania. This is a double-blind 6-week fMRI trial with 24 unmedicated manic patients randomized to risperidone or divalproex, and 14 healthy controls (HC) matched for IQ and demographic factors (mean age: 13.1±3.3 years). A pediatric affective color matching task, in which subjects matched the color of a positive, negative or neutral word with one of two colored circles, was administered. The primary clinical measure was the Young Mania Rating Scale (YMRS). The risperidone group, relative to HC, showed an increase in activation from pre- to post-treatment in right pregenual and subgenual anterior cingulate cortex and decreased activation in bilateral middle frontal gyrus during the negative condition; and decreased activation in left inferior and medial, and right middle frontal gyri, left inferior parietal lobe, and right striatum with positive condition. In the divalproex group, relative to HC, there was an increased activation in right superior temporal gyrus in the negative condition; and in left medial frontal gyrus and right precuneus with the positive condition. Greater pre-treatment right amygdala activity with negative and positive condition in the risperidone group, and left amygdala activity with positive condition in divalproex group, predicted poor response on YMRS. Risperidone and divalproex yield differential patterns of prefrontal activity during an emotion processing task in pediatric mania. Increased amygdala activity at baseline is a potential biomarker predicting poor treatment response to both the risperidone and divalproex.
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影响因子：
4.8
作者：
Northoff, G;Heinzel, A;Schlaug, G
通讯作者：
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影响因子：
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DOI：
10.1017/s1355617709991019
发表时间：
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作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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