Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress.
Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress.
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DOI：
10.3390/molecules19067757
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发表时间：
2014-06-10
期刊：
影响因子：
--
通讯作者：
Huang Z
中科院分区：
文献类型：
--
作者：
Xiao L;Li H;Zhang J;Yang F;Huang A;Deng J;Liang M;Ma F;Hu M;Huang Z
多聚谷氨酰胺（polyQ）聚集在亨廷顿病和其他polyQ疾病的病理过程中起着关键作用。因此，旨在恢复功能障碍和减少由polyQ毒性介导的应激的策略对于蛋白毒性疾病具有治疗意义。红景天苷是一种来源于红景天的糖苷，具有多种生物活性，包括抗氧化活性。使用转基因秀丽隐杆线虫模型，我们在这里表明，红景天苷能够减少神经元死亡和行为功能障碍介导的polyQ在ASH神经元中表达，但神经保护作用是不相关的预防polyQ聚集本身。进一步的实验表明红景天苷对C. elegans模型中的抗氧化能力，包括降低ROS水平和百草枯诱导的死亡率，增加抗氧化酶活性和减少脂质过氧化。这些结果表明，红景天苷通过氧化应激途径发挥其针对polyQ毒性的神经保护功能。
Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington’s disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction and reducing stresses mediated by polyQ toxicity are of therapeutic interest for proteotoxicity diseases. Salidroside, a glycoside from Rhodiola rosea, has been shown to have a variety of bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able to reduce neuronal death and behavioral dysfunction mediated by polyQ expressed in ASH neurons, but the neuroprotective effect is not associated with prevention of polyQ aggregation per se. Further experiments reveal that the neuroprotective effect of salidroside in C. elegans models involves its antioxidant capabilities, including decrease of ROS levels and paraquat-induced mortality, increase of antioxidant enzyme activities and reduction of lipid peroxidation. These results demonstrate that salidroside exerts its neuroprotective function against polyQ toxicity via oxidative stress pathways.
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影响因子：
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作者：
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期刊：
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