Macular Ganglion Cell -Inner Plexiform Layer Thickness Is Associated with Clinical Progression in Mild Cognitive Impairment and Alzheimers Disease.
Macular Ganglion Cell -Inner Plexiform Layer Thickness Is Associated with Clinical Progression in Mild Cognitive Impairment and Alzheimers Disease.
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DOI：
10.1371/journal.pone.0162202
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kim NR
中科院分区：
文献类型：
--
作者：
Choi SH;Park SJ;Kim NR
我们研究了黄斑神经节细胞内丛状层（GCIPL）和视乳头周围视网膜神经纤维层（RNFL）厚度与轻度认知功能障碍（MCI）和阿尔茨海默病（AD）疾病进展的关系。我们招募了42名AD患者，26名MCI患者和66名正常老年人对照。在基线时，通过光谱域光学相干断层扫描测量所有参与者的RNFL和GCIPL厚度。MCI或AD患者在基线时接受临床和神经心理学测试，此后每年一次，持续2年。临床痴呆评定量表-盒子总和（CDR-SB）评分与平均GCIPL厚度（β =-0.15，p < 0.05）以及颞上、鼻上和鼻下部分的GCIPL厚度呈显著负相关。复合记忆评分与GCIPL平均厚度和颞上、鼻下和颞下区GCIPL厚度呈显著正相关。与稳定型MCI患者相比，转换为AD的MCI患者的颞侧RNFL厚度、平均和最小GCIPL厚度以及基线时鼻下、下和颞下部分的GCIPL厚度显著降低。CDR-SB从基线到2年的变化与平均（β =-0.150，p = 0.006）和最小GCIPL厚度以及基线时颞上、上级、鼻上和鼻下部分的GCIPL厚度呈显著负相关。我们的数据表明，黄斑GCIPL厚度代表了一个有前途的生物标志物，用于监测MCI和AD的进展。
We investigated the association of the macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thicknesses with disease progression in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We recruited 42 patients with AD, 26 with MCI, and 66 normal elderly controls. The thicknesses of the RNFL and GCIPL were measured via spectral-domain optic coherent tomography in all participants at baseline. The patients with MCI or AD underwent clinical and neuropsychological tests at baseline and once every year thereafter for 2 years. The Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) score exhibited significant negative relationships with the average GCIPL thickness (β = -0.15, p < 0.05) and the GCIPL thickness in the superotemporal, superonasal, and inferonasal sectors. The composite memory score exhibited significant positive associations with the average GCIPL thickness and the GCIPL thickness in the superotemporal, inferonasal, and inferotemporal sectors. The temporal RNFL thickness, the average and minimum GCIPL thicknesses, and the GCIPL thickness in the inferonasal, inferior, and inferotemporal sectors at baseline were significantly reduced in MCI patients who were converted to AD compared to stable MCI patients. The change of CDR-SB from baseline to 2 years exhibited significant negative associations with the average (β = -0.150, p = 0.006) and minimum GCIPL thicknesses as well as GCIPL thickness in the superotemporal, superior, superonasal, and inferonasal sectors at baseline. Our data suggest that macular GCIPL thickness represents a promising biomarker for monitoring the progression of MCI and AD.
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影响因子：
3.7
作者：
Coppola G;Di Renzo A;Ziccardi L;Martelli F;Fadda A;Manni G;Barboni P;Pierelli F;Sadun AA;Parisi V
通讯作者：
Parisi V
影响因子：
4.5
作者：
Ahn HJ;Chin J;Park A;Lee BH;Suh MK;Seo SW;Na DL
通讯作者：
Na DL
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
2.9
作者：
BLANKS, JC;HINTON, DR;MILLER, CA
通讯作者：
MILLER, CA
影响因子：
2.9
作者：
Iseri, PK;Altinas, Ö;Yüksel, N
通讯作者：
Yüksel, N