Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor.
Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor.
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基于灌注距离的修正微血管密度：一个优选的 NSCLC 预后因素
DOI：
10.21037/atm-21-6566
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发表时间：
2022-01
影响因子：
--
通讯作者：
Fang L
中科院分区：
文献类型：
--
作者：
Tong Y;Yang D;Mi X;Song Y;Xin W;Zhong L;Shi Z;Xu G;Ding H;Fang L
尽管血液灌注在肿瘤进展中起着至关重要的作用，但典型的血液灌注指标，如微血管密度（MVD）或微血管面积（MVA）在非小细胞肺癌（NSCLC）患者中的预后价值尚不清楚。本研究建立了一种基于灌注距离的改良MVD （mMVD）测量方法，并确定其在非小细胞肺癌患者中的预后价值。方法对100例非小细胞肺癌患者进行回顾性研究。应用CD31免疫组化染色观察非小细胞肺癌患者肿瘤内微血管。血流灌注距离评估为每条血管到最近的癌细胞（Dmvcc）的距离，并确定预后的截止值。除总MVD （tMVD）外，截止dmvcc内癌细胞附近的微血管也被计算为mMVD。评估和比较死亡率和复发率的预测值。结果Dmvcc范围为1.6 ~ 269.8µm（中位数为13.1µm）。mMVD（范围：2-70，中位数23）根据截止- dmvcc（~20µm）从tMVD计算。与tMVD相比，更大比例的mMVD （80% vs. 2.9%）在总生存期中发挥了重要作用，受试者工作特征（ROC）曲线下面积（AUC）得到改善（0.74 vs. 0.56）。高mMVD是总生存期（OS）和无进展生存期（PFS）的独立阳性指标。相比之下，tMVD仅在最佳截止点与PFS相关。结论与tMVD相比，基于灌注距离的mMVD具有更好的敏感性、特异性和临床适用性，是NSCLC患者预后的一个有希望的因素。本研究为肿瘤血管灌注在非小细胞肺癌患者预后中的作用提供了新的见解。
Background Despite the vital role of blood perfusion in tumor progression, the prognostic value of typical blood perfusion markers, such as microvessel density (MVD) or microvessel area (MVA), in patients with non-small cell lung cancer (NSCLC) is still unclear. This study established a modified MVD (mMVD) measurement based on perfusion distance and determined its prognostic value in patients with NSCLC. Methods A total of 100 patients with NSCLC were enrolled in this retrospective study. The intratumor microvessels of NSCLC patients were visualized using immunohistochemical staining for CD31. The blood perfusion distance was evaluated as the distance from each vessel to its nearest cancer cell (Dmvcc), and the cutoff value for prognosis was determined. Apart from the total MVD (tMVD), microvessels near cancer cells within the cutoff-Dmvcc were counted as mMVD. Predictive values for mortality and recurrence were evaluated and compared. Results The Dmvcc ranged from 1.6 to 269.8 µm (median, 13.1 µm). The mMVD (range: 2–70; median 23) was counted from tMVD according to the cutoff-Dmvcc (~20 µm). Compared with tMVD, a larger fraction of mMVD (80% vs. 2.9%) played a significant role in overall survival, with an improved area under the receiver operating characteristic (ROC) curve (AUC) (0.74 vs. 0.56). A high mMVD was an independent positive indicator of overall survival (OS) and progression-free survival (PFS). In contrast, tMVD was only related to PFS at the optimal cutoff. Conclusions Perfusion-distance-based mMVD is a promising prognostic factor for NSCLC patients with superior sensitivity, specificity, and clinical applicability compared to tMVD. This study provides novel insights into the prognostic role of tumor vessel perfusion in patients with NSCLC.
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影响因子：
11.5
作者：
Bhattacharya, A;T贸th, K;Rustum, YM
通讯作者：
Rustum, YM
微血管到癌细胞的远距离预示着非小细胞肺癌患者的不良预后
影响因子：
4.7
作者：
Ding H;Sun J;Song Y;Xin W;Zhu J;Zhong L;Chen Y;Zhang Y;Tong Y;Fang L
通讯作者：
Fang L
影响因子：
45.3
作者：
Swinson, DEB;Jones, JL;O'Byrne, KJ
通讯作者：
O'Byrne, KJ
某些人类肺癌的组织学结构以及对放射疗法的可能影响。
影响因子：
8.8
作者：
THOMLINSON, R H;GRAY, L H
通讯作者：
GRAY, L H
DOI：
10.4049/jimmunol.2000185
发表时间：
2020-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Steinberger KJ;Forget MA;Bobko AA;Mihalik NE;Gencheva M;Roda JM;Cole SL;Mo X;Hoblitzell EH;Evans R;Gross AC;Moldovan L;Marsh CB;Khramstov VV;Eubank TD
通讯作者：
Eubank TD