Inhibitory effect of bucillamine on laser-induced choroidal neovascularization in rats
Inhibitory effect of bucillamine on laser-induced choroidal neovascularization in rats
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布西拉明对激光诱导大鼠脉络膜新生血管的抑制作用
DOI：
10.1076/ceyr.24.1.1.5434
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发表时间：
2002
影响因子：
2
通讯作者：
A. Yoshida
中科院分区：
文献类型：
--
作者：
T. Hikichi;F. Mori;Mai Sasaki;A. Takamiya;Masao Nakamura;N. Shishido;M. Takeda;Y. Horikawa;H. Matsuoka;A. Yoshida
目的.我们研究了布西拉明对激光诱导的大鼠脉络膜新生血管（CNV）形成的抑制作用。方法.布西拉明给药（约150？在光凝前1周开始给予（2 mg/kg/天），并持续至研究结束。对照组接受饮用水。光凝后2周，采用荧光素和吲哚菁绿色血管造影同时评价脉络膜新生血管的发展，并组织学测量病变的最大厚度。结果对照组CNV形成率为99.5 ± 0.2%，布西拉明组为64.3 ± 15.1%（P < 0.01）。组织学检查显示，治疗组CNV病变厚度为23.4 ± 6.5 μm（平均值±标准差），与对照组（60.8 ± 9.2 μm）相比明显减少（P < 0.01）。结论.我们的研究结果表明，布西拉明可以抑制激光诱导的大鼠CNV的发展。
Purpose. We investigated the inhibitory effects of bucillamine on formation of laser-induced choroidal neovascularization (CNV) in a rat model. Methods. Bucillamine administration (approximately 150?mg/kg/day) was started 1 week before photocoagulation and continued to the end of the study. Control groups received drinking water. Two weeks after photocoagulation, choroidal neovascularization development was evaluated using simultaneous fluorescein and indocyanine green angiography, and the maximal thickness of the lesions was measured histologically. Results. The incidence of CNV formation was 99.5 ± 0.2% [mean ± standard deviation (SD)] in control rats and 64.3 ± 15.1% with bucillamine (P < 0.01). Histological study showed that the thickness of the CNV lesions was 23.4 ± 6.5 µm (mean ± SD) in the bucillamine-treated rats, which was significantly decreased compared to that in controls (60.8 ± 9.2 µm) (P < 0.01). Conclusions. Our results suggest that bucillamine may inhibit the development of laser-induced CNV in rats.
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作者：
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DOI：
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发表时间：
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期刊：
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