Triclosan exposure and allergic sensitization in Norwegian children.
Triclosan exposure and allergic sensitization in Norwegian children.
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DOI：
10.1111/all.12058
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发表时间：
2013-01
期刊：
影响因子：
12.4
通讯作者：
Lødrup Carlsen KC
中科院分区：
文献类型：
--
作者：
Bertelsen RJ;Longnecker MP;Løvik M;Calafat AM;Carlsen KH;London SJ;Lødrup Carlsen KC
接触用于个人护理产品的合成抗菌化学物质三氯生，被认为会导致过敏性疾病。我们调查了三氯生暴露是否与10岁挪威儿童的过敏致敏和症状有关。在2001 - 2004年收集的623名儿童的第一次晨尿中测定了三氯生浓度。采用Logistic回归模型，控制尿液比重、父母过敏性疾病、母亲教育程度和家庭收入，拟合过敏致敏（皮肤点刺试验阳性或血清特异性IgE≥0.35 kU/L，对15种评估的吸入物和食物过敏原中的至少一种）、当前鼻炎和当前哮喘（问卷调查和运动挑战试验）。与参照组（<检出限）相比，三氯生浓度第四个四分位数组过敏致敏的调整优势比（aOR）为2.0(95%可信区间（CI）： 1.1, 3.4)，三氯生浓度每增加log10单位的调整优势比（aOR）为1.2 （95% CI: 1.0, 1.4）。当前鼻炎的aOR在第四个四分位数为1.9 (95% CI: 1.1, 3.4)，三氯生每增加log10单位为1.2 （95% CI:0.97, 1.4）。三氯生浓度与过敏性致敏有关，尤其是吸入性和季节性过敏原，而不是食物过敏原。当前的鼻炎与最高水平的三氯生有关，而与当前的哮喘没有关联。这些结果与最近其他研究的发现一致，并为三氯生与过敏之间的联系提供了额外的证据。
Exposure to the synthetic antimicrobial chemical, triclosan, used in personal care products, has been hypothesized to lead to allergic disease. We investigated whether triclosan exposure was associated with allergic sensitization and symptoms in 10-year old Norwegian children. Urinary concentrations of triclosan were measured in one first morning void from 623 children, collected 2001– 2004. Logistic regression models, controlling for urine specific gravity, parental allergic disease, maternal education, and household income, were fitted for allergic sensitization (either skin prick test positivity or serum specific IgE ≥0.35 kU/L to at least one of 15 evaluated inhalant and food allergens), current rhinitis, and current asthma (questionnaire and exercise challenge test). The adjusted odds ratio (aOR) for allergic sensitization among those in the fourth quartile of triclosan concentration was 2.0 (95% confidence interval (CI): 1.1, 3.4) compared with the reference group (< the limit of detection) and the aOR per log10 unit increase in triclosan was 1.2 (95% CI: 1.0, 1.4). The aOR for current rhinitis was 1.9 (95% CI: 1.1, 3.4) for the fourth quartile and 1.2 (95% CI:0.97, 1.4) per log10 unit increase in triclosan. Triclosan concentrations were associated with allergic sensitization, especially inhalant and seasonal allergens rather thanfood allergens. Current rhinitis was associated with the highest levels of triclosan, whereas no association was seen for current asthma. These results are consistent with recent findings in other studies and provide additional evidence for an association between triclosan and allergy.
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影响因子：
4.3
作者：
Moss, T;Howes, D;Williams, FM
通讯作者：
Williams, FM
DOI：
10.1097/ede.0b013e3181ce97d8
发表时间：
2010-07
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Nie L;Chu H;Liu C;Cole SR;Vexler A;Schisterman EF
通讯作者：
Schisterman EF
影响因子：
10.4
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
通讯作者：
Needham LL
DOI：
10.1111/j.1365-2125.1987.tb03094.x
发表时间：
1987-05-01
影响因子：
3.4
作者：
GILBERT, RJ;WILLIAMS, PEO
通讯作者：
WILLIAMS, PEO
影响因子：
14.2
作者：
Savage, Jessica H.;Matsui, Elizabeth C.;Wood, Robert A.;Keet, Corinne A.
通讯作者：
Keet, Corinne A.