Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder.
Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder.
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DOI：
10.1016/j.nicl.2013.04.007
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发表时间：
2013-01-01
影响因子：
4.2
通讯作者：
Leibenluft, Ellen
中科院分区：
文献类型：
--
作者：
Thomas, Laura A.;Kim, Pilyoung;Bones, Brian L.;Hinton, Kendra E.;Milch, Hannah S.;Reynolds, Richard C.;Adleman, Nancy E.;Marsh, Abigail A.;Blair, R. J. R.;Pine, Daniel S.;Leibenluft, Ellen
儿童精神病学中的一个主要争议是，双相情感障碍 (BD) 在儿童中是否表现为严重的、非发作性的烦躁（此处称为严重情绪失调，SMD），而不是像成人那样表现为躁狂发作。经典的、发作性的 BD 和 SMD 都是严重的情绪障碍，其特征是处理情绪刺激的缺陷。神经影像技术可用于测试介导这些缺陷的病理生理学在两种表型中是否相似。 BD 中面部情绪处理过程中的杏仁核功能障碍已得到充分记录，但对于长期易激惹的青少年中的杏仁核功能障碍知之甚少。我们比较了 SMD (n = 19)、BD (n = 19) 和健康志愿者 (HV; n = 15) 青少年在进行愤怒、恐惧和中性表情的内隐面部情绪处理任务时的神经激活情况。在右侧杏仁核中，SMD 和 BD 在所有表达中均表现出比 HV 更高的活性。然而，SMD 和 BD 在后扣带皮层、后岛叶和下顶叶方面彼此不同，HV 也不同。在这些区域中，只有 SMD 对恐惧表情表现出失活反应，而只有 BD 对愤怒表情表现出失活反应。因此，在内隐面部情绪处理过程中，BD 青少年和 SMD 青少年表现出相似的杏仁核功能障碍，但参与信息监控和整合的区域表现出不同的异常。患有严重情绪失调（SMD）、双相情感障碍（BD）的青少年作为对照。具有愤怒、恐惧、中性情绪的内隐面部情绪处理功能磁共振成像任务。在杏仁核中，与对照组相比，SMD 和 BD 在所有表达中都具有更大的活性。在全脑分析中，与其他组相比，SMD 的活动减少，BD 的活动增加。
A major controversy in child psychiatry is whether bipolar disorder (BD) presents in children as severe, non-episodic irritability (operationalized here as severe mood dysregulation, SMD), rather than with manic episodes as in adults. Both classic, episodic BD and SMD are severe mood disorders characterized by deficits in processing emotional stimuli. Neuroimaging techniques can be used to test whether the pathophysiology mediating these deficits are similar across the two phenotypes. Amygdala dysfunction during face emotion processing is well-documented in BD, but little is known about amygdala dysfunction in chronically irritable youth. We compared neural activation in SMD (n = 19), BD (n = 19), and healthy volunteer (HV; n = 15) youths during an implicit face-emotion processing task with angry, fearful and neutral expressions. In the right amygdala, both SMD and BD exhibited greater activity across all expressions than HV. However, SMD and BD differed from each other and HV in posterior cingulate cortex, posterior insula, and inferior parietal lobe. In these regions, only SMD showed deactivation in response to fearful expressions, whereas only BD showed deactivation in response to angry expressions. Thus, during implicit face emotion processing, youth with BD and those with SMD exhibit similar amygdala dysfunction but different abnormalities in regions involved in information monitoring and integration. Youths with severe mood dysregulation (SMD), bipolar disorder (BD), controls. Implicit face-emotion processing fMRI task with angry, fearful, neutral emotions. In R amygdala, SMD and BD had greater activity across all expressions vs controls. In whole brain analysis SMD had decreased, BD increased activity vs. other groups.
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DOI：
10.1017/s1355617709991019
发表时间：
2010-01
影响因子：
2.6
作者：
Passarotti, Alessandra M.;Sweeney, John A.;Pavuluri, Mani N.
通讯作者：
Pavuluri, Mani N.
影响因子：
10.6
作者：
Brotman, Melissa A.;Schmajuk, Mariana;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
影响因子：
17.7
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Blair, R. J. R.
通讯作者：
Blair, R. J. R.
影响因子：
64.8
作者：
Morris, JS;Frith, CD;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
10.6
作者：
Pavuluri, Mani N.;O'Connor, Megan Marlow;Sweeney, John A.
通讯作者：
Sweeney, John A.