Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy.
Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy.
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针对细胞外基质硬度和机械传感器来改善癌症治疗
DOI：
10.1186/s13045-022-01252-0
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发表时间：
2022-03-24
影响因子：
28.5
通讯作者：
Hua H
中科院分区：
文献类型：
--
作者：
Jiang Y;Zhang H;Wang J;Liu Y;Luo T;Hua H
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion. Both ECM itself and ECM stiffening-induced mechanical stimuli may activate cell membrane receptors and mechanosensors such as integrin, Piezo1 and TRPV4, thereby modulating the malignant phenotype of tumor and stromal cells. A better understanding of how ECM stiffness regulates tumor progression will contribute to the development of new therapeutics. The rapidly expanding evidence in this research area suggests that the regulators and effectors of ECM stiffness represent potential therapeutic targets for cancer. This review summarizes recent work on the regulation of ECM stiffness in cancer, the effects of ECM stiffness on tumor progression, cancer immunity and drug resistance. We also discuss the potential targets that may be druggable to intervene ECM stiffness and tumor progression. Based on these advances, future efforts can be made to develop more effective and safe drugs to interrupt ECM stiffness-induced oncogenic signaling, cancer progression and drug resistance.
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影响因子：
10.9
作者：
Dong B;Li S;Zhu S;Yi M;Luo S;Wu K
通讯作者：
Wu K
影响因子：
6
作者：
Dombroski JA;Hope JM;Sarna NS;King MR
通讯作者：
King MR
DOI：
10.1016/j.bbrc.2009.07.010
发表时间：
2009-09-11
影响因子：
3.1
作者：
Craig, David H.;Shiratsuchi, Hiroe;Basson, Marc D.
通讯作者：
Basson, Marc D.
影响因子：
3.7
作者：
Barcus CE;Holt EC;Keely PJ;Eliceiri KW;Schuler LA
通讯作者：
Schuler LA
由机械敏感离子通道 PIEZO1 和组织力学介导的前馈机制促进胶质瘤侵袭。
影响因子：
16.2
作者：
Chen, Xin;Wanggou, Siyi;Huang, Xi
通讯作者：
Huang, Xi