The demographic history of house mice (Mus musculus domesticus) in eastern North America.
The demographic history of house mice (Mus musculus domesticus) in eastern North America.
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DOI：
10.1093/g3journal/jkac332
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发表时间：
2023-02-09
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--
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西欧家鼠（Mus musculus musculus）是一种分布广泛的人类家鼠，最近被引入北美。它被引入美洲被认为是由于欧洲人在世纪早期开始的跨大西洋运动。为了研究这一殖民历史的细节，我们研究人口结构，探索相关的人口模型，并推断在美国东部的家鼠种群之间的分歧的时间使用公布的外显子组序列从五个北美种群和两个欧洲种群。对于北美种群的家鼠，核苷酸变异水平较低，低频等位基因比欧洲种群更不常见。这些模式提供了与家鼠进入北美的运动有关的温和瓶颈的证据。一些分析显示，一个北美种群是遗传混合的，这表明至少有两个来自欧洲的来源种群被独立地引入北美东部。估计北美和德国人口之间的分歧时间在1,000年至7,000年前之间，与估计的德国和法国人口之间的分歧时间重叠。比较不同北美人口的人口模型显示，这些人口主要在过去500年内彼此分化，与西欧定居者到达北美的时间一致。总之，这些结果支持了最近引入西欧家鼠到北美东部，突出了人类迁移和殖民化对入侵性人类寄生虫传播的影响。
The Western European house mouse (Mus musculus domesticus) is a widespread human commensal that has recently been introduced to North America. Its introduction to the Americas is thought to have resulted from the transatlantic movements of Europeans that began in the early 16th century. To study the details of this colonization history, we examine population structure, explore relevant demographic models, and infer the timing of divergence among house mouse populations in the eastern United States using published exome sequences from five North American populations and two European populations. For North American populations of house mice, levels of nucleotide variation were lower, and low-frequency alleles were less common than for European populations. These patterns provide evidence of a mild bottleneck associated with the movement of house mice into North America. Several analyses revealed that one North American population is genetically admixed, which indicates at least two source populations from Europe were independently introduced to eastern North America. Estimated divergence times between North American and German populations ranged between ∼1,000 and 7,000 years ago and overlapped with the estimated divergence time between populations from Germany and France. Demographic models comparing different North American populations revealed that these populations diverged from each other mostly within the last 500 years, consistent with the timing of the arrival of Western European settlers to North America. Together, these results support a recent introduction of Western European house mice to eastern North America, highlighting the effects of human migration and colonization on the spread of an invasive human commensal.
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影响因子：
4.5
作者：
Gutenkunst RN;Hernandez RD;Williamson SH;Bustamante CD
通讯作者：
Bustamante CD
影响因子：
2.1
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通讯作者：
Cooper A
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通讯作者：
Tautz, Diethard
影响因子：
3.7
作者：
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通讯作者：
Lenstra, Johannes A.