Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as novel risk markers for diabetic nephropathy in patients with type 2 diabetes.
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as novel risk markers for diabetic nephropathy in patients with type 2 diabetes.
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中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值作为2型糖尿病患者糖尿病肾病的新型风险标志物
DOI：
10.1016/j.heliyon.2021.e07564
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发表时间：
2021-07
期刊：
影响因子：
4
通讯作者：
Hessenow R
中科院分区：
文献类型：
--
作者：
Jaaban M;Zetoune AB;Hesenow S;Hessenow R
糖尿病会引起严重的并发症，如糖尿病肾病。糖尿病肾病是慢性肾脏病最常见的原因。炎症在糖尿病肾病的发生和发展中起着至关重要的作用。本研究的目的是评估炎症标志物（血小板-淋巴细胞比率和血小板-淋巴细胞比率）与叙利亚糖尿病肾病患者的关系。共158例2型糖尿病患者，根据尿白蛋白与肌酐比值分为三组：A组，正常白蛋白尿的2型糖尿病患者（尿白蛋白/肌酐比值<30 mg/g）;组B，2型糖尿病患者伴微量白蛋白尿（尿白蛋白/肌酐比值= 30-300 mg/g）; C组，2型糖尿病患者伴大量白蛋白尿（尿白蛋白/肌酐比值≥300 mg/g）。记录并比较三组间的炎症标志物水平（嗜中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率）。在嗜中性粒细胞与淋巴细胞比率（p = 0.000）和血小板与淋巴细胞比率（p = 0.000）方面，检测到组间存在显著差异。炎症标志物和微量白蛋白尿预测的受试者工作特征曲线分析显示，嗜中性粒细胞与淋巴细胞比率的曲线下面积（AUC）为0.869（置信区间：0.813-0.926，p = 0.000），血小板与淋巴细胞比率的曲线下面积（AUC）为0.739（置信区间：0.662-0.815，p = 0.000）。血小板/淋巴细胞比值和血小板/淋巴细胞比值升高与糖尿病肾病的发生显著相关，血小板/淋巴细胞比值和血小板/淋巴细胞比值升高可作为糖尿病肾病的预测指标和预后危险指标。糖尿病肾病，尿白蛋白/肌酐比值，中性粒细胞/淋巴细胞比值，血小板/淋巴细胞比值。
Diabetes mellitus causes serious complications such as diabetic nephropathy. Diabetic nephropathy is now the most common reason of chronic kidney disease. Inflammation plays a crucial role in development and progression of diabetic nephropathy. The aim of this study was to evaluate the relationship of Inflammatory markers (neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio) with diabetic nephropathy in Syrian patients. A total of 158 patients with type 2 diabetes mellitus were distributed into three groups according to urinary albumin-to-creatinine ratio: Group A, type 2 diabetic patients with normoalbuminuria (urinary albumin-to-creatinine ratio <30 mg/g); Group B, type 2 diabetic patients with microalbuminuria (urinary albumin-to-creatinine ratio = 30–300 mg/g); Group C, type 2 diabetic patients with macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g). Levels of inflammatory markers (neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio) were recorded and compared among the three groups. Significant differences were detected between the groups in terms of neutrophil-to-lymphocyte ratio (p = 0.000) and platelet-to-lymphocyte ratio (p = 0.000). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction demonstrated an area under curve (AUC) of 0.869 for neutrophil-to-lymphocyte ratio (confidence interval: 0.813–0.926, p = 0.000) and 0.739 for platelet-to-lymphocyte ratio (confidence interval: 0.662–0.815, p = 0.000). Increased neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were significantly correlated with diabetic nephropathy, and high neutrophil-to-lymphocyte ratio & platelet-to-lymphocyte ratio may be served as a predictor and a prognostic risk marker of diabetic nephropathy. Diabetic nephropathy, Urinary albumin-to-creatinine ratio, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio.
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影响因子：
11.1
作者：
Fiseha T
通讯作者：
Fiseha T
影响因子：
2
作者：
Mineoka, Yusuke;Ishii, Michiyo;Fukui, Michiaki
通讯作者：
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影响因子：
5.4
作者：
Ozturk, Z. A.;Kuyumcu, M. E.;Ariogul, S.
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影响因子：
1.3
作者：
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通讯作者：
Tonbul, H. Zeki
影响因子：
4.3
作者：
Gluhovschi C;Gluhovschi G;Petrica L;Timar R;Velciov S;Ionita I;Kaycsa A;Timar B
通讯作者：
Timar B