The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy.
The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy.
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DOI：
10.1155/2021/5390195
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Li W;Li X;Cui F;Xu Z;Dong N;Li C
探讨前列腺癌患者长期雄激素剥夺治疗（ADT）与眼表特征的关系。 共选择了30例接受ADT治疗的男性前列腺癌患者。采用眼表疾病指数（OSDI）对所有候选者进行评分，随后将其分为两组，其中9例有症状患者（评分>12）和21例无症状患者（评分≤ 12）。另选取20例年龄相匹配的健康男性作为对照组。每个候选人进行了评估眼睑边缘异常，泪膜破裂时间（NI-BUT），泪半月板高度（TMH），meibosore，睑脂可表达性，蠕形螨感染。 ADT组NI-BUT明显短于对照组。ADT组的OSDI、睑缘异常、睑缘可展性、睑缘评分均显著高于对照组（P < 0.05）。症状性ADT组NI-BUT明显短于无症状性ADT组（P < 0.05）。有症状ADT组睑缘评分和睑缘可表达性评分均显著高于无症状ADT组（P < 0.05）。有症状ADT组蠕形螨检出率高于无症状ADT组（P <0. 05），患者服用ADT时间与Meibo评分呈正相关，与NI-BUT呈负相关。 雄激素水平与相对睑板腺功能的显著变化相关。接受ADT治疗的前列腺癌患者的主观症状，如干燥和异物感更明显，这可能是由MGD和蠕形螨感染引起的。建议在使用ADT的前列腺癌患者中，通过NI-BUT和睑板腺形态和功能的检查，更多地关注眼表，以期提供更全面的预防和治疗方案。
To investigate the association of long-term androgen deprivation therapy (ADT) with ocular surface characteristics in prostate cancer patients. A total of 30 male prostate cancer patients who received ADT were selected. All candidates were scored using the Ocular Surface Disease Index (OSDI) and subsequently divided into two groups containing 9 symptomatic patients (scores >12) and 21 asymptomatic patients (scores ≤ 12). Another 20 healthy age-matched males were selected as the control group. Each candidate was assessed with respect to eyelid margin abnormality, tear film break-up time (NI-BUT), tear meniscus height (TMH), meiboscore, meibum expressibility, and demodex infection. The NI-BUT in the ADT group was significantly shorter than that in the control group. The scores for OSDI, eyelid margin abnormality, meibum expressibility, and meiboscores were significantly higher in the ADT group (P < 0.05). Moreover, the NI-BUT in the symptomatic ADT group was significantly shorter than that in the asymptomatic ADT group (P < 0.05). The meiboscores and meibum expressibility score in the symptomatic ADT group were significantly higher than those in the asymptomatic ADT group (P < 0.05). The presence of demodex in the symptomatic ADT group was also higher than that in the asymptomatic ADT group (P < 0.05).The length of time that patients had been taking ADT was positively correlated with meiboscores and negatively correlated with NI-BUT. Androgen levels were associated with significant changes in relative meibomian gland function. Subjective symptoms, such as dryness and foreign body sensation, were more obvious in prostate cancer patients receiving ADT, which may be caused by MGD and demodex infection. It's recommended that more attention be paid to the ocular surface in prostate cancer patients taking ADT by performing examination of NI-BUT and meibomian gland morphology and function with a view to providing more comprehensive prevention and treatment protocols.
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影响因子：
4.4
作者：
Dougherty, Bradley E.;Nichols, Jason J.;Nichols, Kelly K.
通讯作者：
Nichols, Kelly K.
影响因子：
5.8
作者：
Krenzer, KL;Dana, MR;Sullivan, DA
通讯作者：
Sullivan, DA
影响因子：
2.8
作者：
Gao, Ying-Ying;Di Pascuale, Mario A.;Tseng, Scheffer C. G.
通讯作者：
Tseng, Scheffer C. G.
影响因子：
13.7
作者：
Arita, Reiko;Itoh, Kouzo;Amano, Shiro
通讯作者：
Amano, Shiro
DOI：
10.1111/j.1749-6632.2002.tb04217.x
发表时间：
2002-01-01
期刊：
NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS
影响因子：
--
作者：
Sullivan, DA;Sullivan, BD;Dana, MR
通讯作者：
Dana, MR