Age at menarche and type 2 diabetes risk: the EPIC-InterAct study.
Age at menarche and type 2 diabetes risk: the EPIC-InterAct study.
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DOI：
10.2337/dc13-0446
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发表时间：
2013-11
期刊：
影响因子：
16.2
通讯作者：
InterAct Consortium
中科院分区：
文献类型：
--
作者：
Elks CE;Ong KK;Scott RA;van der Schouw YT;Brand JS;Wark PA;Amiano P;Balkau B;Barricarte A;Boeing H;Fonseca-Nunes A;Franks PW;Grioni S;Halkjaer J;Kaaks R;Key TJ;Khaw KT;Mattiello A;Nilsson PM;Overvad K;Palli D;Quirós JR;Rinaldi S;Rolandsson O;Romieu I;Sacerdote C;Sánchez MJ;Spijkerman AM;Tjonneland A;Tormo MJ;Tumino R;van der A DL;Forouhi NG;Sharp SJ;Langenberg C;Riboli E;Wareham NJ;InterAct Consortium
初潮年龄越小，作为女孩青春期时间的标志，与以后患2型糖尿病的风险越高有关。我们的目的是确认这种关联，并检查是否可以用肥胖来解释。欧洲癌症与营养前瞻性研究（EPIC）-InterAct病例队列研究包括来自8个欧洲国家26个研究中心的12，403例2型糖尿病病例和16，154例分层子队列。我们在15，168名女性（n = 5，995例）中使用Prentice加权考克斯回归分析来检验初潮年龄与2型糖尿病发病率之间的关系。以序贯方式调整模型的潜在混杂因素和中介因素，包括成人BMI。InterAct国家的平均初潮年龄范围为12.6至13.6岁。每年以后，月经初潮与0.32 kg/m2的成人BMI降低相关。初潮最早的五分之一妇女（8-11岁，n = 2，418）与中间五分之一的人相比，2型糖尿病的发病率高70%（13岁，n = 3，634），根据招募时的年龄、研究中心以及一系列生活方式和生殖因素进行调整（风险比[HR]，1.70; 95% CI，1.49-1.94; P < 0.001）。调整BMI可部分减弱这种关联（HR，1.42; 95%CI，1.18-1.71; P < 0.001）。月经初潮晚于中位年龄并不能预防2型糖尿病。有月经初潮史的女性在成年后患2型糖尿病的风险更高。不到一半的这种关联似乎是由较高的成人BMI介导的，这表明青春期早期发育也可能直接增加2型糖尿病的风险。
Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity. The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from 26 research centers across eight European countries. We tested the association between age at menarche and incident type 2 diabetes using Prentice-weighted Cox regression in 15,168 women (n = 5,995 cases). Models were adjusted in a sequential manner for potential confounding and mediating factors, including adult BMI. Mean menarcheal age ranged from 12.6 to 13.6 years across InterAct countries. Each year later menarche was associated with 0.32 kg/m2 lower adult BMI. Women in the earliest menarche quintile (8–11 years, n = 2,418) had 70% higher incidence of type 2 diabetes compared with those in the middle quintile (13 years, n = 3,634), adjusting for age at recruitment, research center, and a range of lifestyle and reproductive factors (hazard ratio [HR], 1.70; 95% CI, 1.49–1.94; P < 0.001). Adjustment for BMI partially attenuated this association (HR, 1.42; 95% CI, 1.18–1.71; P < 0.001). Later menarche beyond the median age was not protective against type 2 diabetes. Women with history of early menarche have higher risk of type 2 diabetes in adulthood. Less than half of this association appears to be mediated by higher adult BMI, suggesting that early pubertal development also may directly increase type 2 diabetes risk.
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影响因子：
2.8
作者：
Saquib, N;Kritz-Silverstein, D;Barrett-Connor, E
通讯作者：
Barrett-Connor, E
影响因子：
13.6
作者：
Peters, Tricia;Brage, Soren;Westgate, Kate;Franks, Paul W.;Gradmark, Anna;Diaz, Maria Jose Tormo;Huerta, Jose Maria;Bendinelli, Benedetta;Vigl, Mattheaus;Boeing, Heiner;Wendel-Vos, Wanda;Spijkerman, Annemieke;Benjaminsen-Borch, Kristin;Valanou, Elisavet;Guillain, Blandine de Lauzon;Clavel-Chapelon, Francoise;Sharp, Stephen;Kerrison, Nicola;Langenberg, Claudia;Arriola, Larraitz;Barricarte, Aurelio;Gonzales, Carlos;Grioni, Sara;Kaaks, Rudolf;Key, Timothy;Khaw, Kay Tee;May, Anne;Nilsson, Peter;Norat, Teresa;Overvad, Kim;Palli, Domenico;Panico, Salvatore;Quiros, Jose Ramon;Ricceri, Fulvio;Sanchez, Maria-Jose;Slimani, Nadia;Tjonneland, Anne;Tumino, Rosario;Feskens, Edith;Riboli, Elio;Ekelund, Ulf;Wareham, Nick
通讯作者：
Wareham, Nick
影响因子：
8.2
作者：
Langenberg, C.;Sharp, S.;Forouhi, N. G.;Franks, P. W.;Schulze, M. B.;Kerrison, N.;Ekelund, U.;Barroso, I.;Panico, S.;Tormo, M. J.;Spranger, J.;Griffin, S.;van der Schouw, Y. T.;Amiano, P.;Ardanaz, E.;Arriola, L.;Balkau, B.;Barricarte, A.;Beulens, J. W. J.;Boeing, H.;Bueno-de-Mesquita, H. B.;Buijsse, B.;Chirlaque Lopez, M. D.;Clavel-Chapelon, F.;Crowe, F. L.;de Lauzon-Guillan, B.;Deloukas, P.;Dorronsoro, M.;Drogan, D.;Froguel, P.;Gonzalez, C.;Grioni, S.;Groop, L.;Groves, C.;Hainaut, P.;Halkjaer, J.;Hallmans, G.;Hansen, T.;Huerta Castano, J. M.;Kaaks, R.;Key, T. J.;Khaw, K. T.;Koulman, A.;Mattiello, A.;Navarro, C.;Nilsson, P.;Norat, T.;Overvad, K.;Palla, L.;Palli, D.;Pedersen, O.;Peeters, P. H.;Quiros, J. R.;Ramachandran, A.;Rodriguez-Suarez, L.;Rolandsson, O.;Romaguera, D.;Romieu, I.;Sacerdote, C.;Sanchez, M. J.;Sandbaek, A.;Slimani, N.;Sluijs, I.;Spijkerman, A. M. W.;Teucher, B.;Tjonneland, A.;Tumino, R.;van der A, D. L.;Verschuren, W. M. M.;Tuomilehto, J.;Feskens, E.;McCarthy, M.;Riboli, E.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
7.2
作者：
Cooper, GS;Ephross, SA;Sandler, DP
通讯作者：
Sandler, DP
影响因子：
5
作者：
Must, A;Phillips, SM;Rand, WM
通讯作者：
Rand, WM