Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future.
Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future.
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DOI：
10.3390/biomedicines11112959
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发表时间：
2023-11-01
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
活性氧在各种眼部神经退行性疾病尤其是青光眼、年龄相关性黄斑变性（AMD）和眼部缺血性中风的发病机制中起重要作用。增加的氧化应激和ROS的积累与这些疾病的进展有关。因此，人们对探索涉及外源性抗氧化剂的潜在治疗和预防策略越来越感兴趣。近年来，针对神经退行性疾病中的活性氧（ROS）的合成治疗性抗氧化剂的开发取得了重大进展。重点领域之一是开发TEMPOL混合衍生物。在眼部疾病的背景下，下一代混合TEMPOL抗氧化剂的应用可能为神经保护提供新的途径。通过靶向ROS并减少视网膜和视神经中的氧化应激，这些化合物具有保护视网膜神经节细胞和小梁网并防止视神经损伤的潜力，减轻与这些疾病相关的不可逆失明。这篇综述旨在强调混合TEMPOL抗氧化剂及其衍生物对眼部神经退行性疾病的潜在影响。
Reactive oxygen species play a significant role in the pathogenesis of various ocular neurodegenerative diseases especially glaucoma, age-related macular degeneration (AMD), and ocular ischemic stroke. Increased oxidative stress and the accumulation of ROS have been implicated in the progression of these diseases. As a result, there has been growing interest in exploring potential therapeutic and prophylactic strategies involving exogenous antioxidants. In recent years, there have been significant advancements in the development of synthetic therapeutic antioxidants for targeting reactive oxygen species (ROS) in neurodegenerative diseases. One area of focus has been the development of hybrid TEMPOL derivatives. In the context of ocular diseases, the application of next-generation hybrid TEMPOL antioxidants may offer new avenues for neuroprotection. By targeting ROS and reducing oxidative stress in the retina and optic nerve, these compounds have the potential to preserve retinal ganglion cells and trabecular meshwork and protect against optic nerve damage, mitigating irreversible blindness associated with these diseases. This review seeks to highlight the potential impact of hybrid TEMPOL antioxidants and their derivatives on ocular neurodegenerative disorders.
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DOI：
10.2147/opth.s59162
发表时间：
2014
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Alm A
通讯作者：
Alm A
DOI：
10.1016/j.dsx.2016.01.028
发表时间：
2016-04-01
影响因子：
10
作者：
Fatani, Sameer Hassan;Babakr, Abdullatif Taha;Almarzouki, Abdalla A.
通讯作者：
Almarzouki, Abdalla A.
影响因子：
3.2
作者：
Digiuni, Maurizio;Fogagnolo, Paolo;Rossetti, Luca
通讯作者：
Rossetti, Luca
影响因子：
3.1
作者：
Chan, Elsa C.;Liu, Guei-Sheung;Dusting, Gregory J.
通讯作者：
Dusting, Gregory J.
影响因子：
17.8
作者：
Datta S;Cano M;Ebrahimi K;Wang L;Handa JT
通讯作者：
Handa JT