Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
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DOI：
10.1126/sciimmunol.abf3698
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发表时间：
2020-12-23
影响因子：
24.8
通讯作者：
Boyton RJ
中科院分区：
文献类型：
--
作者：
Reynolds CJ;Swadling L;Gibbons JM;Pade C;Jensen MP;Diniz MO;Schmidt NM;Butler DK;Amin OE;Bailey SNL;Murray SM;Pieper FP;Taylor S;Jones J;Jones M;Lee WJ;Rosenheim J;Chandran A;Joy G;Di Genova C;Temperton N;Lambourne J;Cutino-Moguel T;Andiapen M;Fontana M;Smit A;Semper A;O'Brien B;Chain B;Brooks T;Manisty C;Treibel T;Moon JC;COVIDsortium investigators;Noursadeghi M;COVIDsortium immune correlates network;Altmann DM;Maini MK;McKnight Á;Boyton RJ
了解轻度/无症状感染SARS-CoV-2后的免疫性质对控制大流行至关重要。我们分析了英国封锁后16-18周136名医护人员（HCW）的T细胞和中和抗体反应，其中76人通过连续抽样捕获了轻度/无症状的SARS-CoV-2感染。中和抗体（nAb）存在于89%以前感染的HCW。无症状感染后的T细胞反应往往低于报告COVID-19病例定义症状的患者，而无论症状如何，nAb滴度都保持不变。T细胞和抗体反应有时不一致。11%的人缺乏nAb，对刺突蛋白没有检测到的T细胞反应，但T细胞对其他SARS-CoV-2抗原有反应。我们的研究结果表明，大多数轻度或无症状SARS-CoV-2感染的个体在轻度或无症状SARS-CoV-2感染后16-18周携带nAb并伴有多特异性T细胞应答。在一些轻度或无症状的COVID-19病例中，中和抗体和T细胞对SARS-CoV-2抗原的反应不偶联。
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection. Uncoupling of neutralizing antibody and T cell responses to SARS-CoV-2 antigens occurs in some mild or asymptomatic cases of COVID-19.
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DOI：
10.3390/v12091011
发表时间：
2020-09-10
期刊：
Viruses
影响因子：
--
作者：
Hyseni I;Molesti E;Benincasa L;Piu P;Casa E;Temperton NJ;Manenti A;Montomoli E
通讯作者：
Montomoli E
影响因子：
5.4
作者：
Figueiredo-Campos P;Blankenhaus B;Mota C;Gomes A;Serrano M;Ariotti S;Costa C;Nunes-Cabaço H;Mendes AM;Gaspar P;Pereira-Santos MC;Rodrigues F;Condeço J;Escoval MA;Santos M;Ramirez M;Melo-Cristino J;Simas JP;Vasconcelos E;Afonso Â;Veldhoen M
通讯作者：
Veldhoen M
影响因子：
9.4
作者：
Addetia A;Crawford KHD;Dingens A;Zhu H;Roychoudhury P;Huang ML;Jerome KR;Bloom JD;Greninger AL
通讯作者：
Greninger AL
影响因子：
7.3
作者：
Carnell GW;Ferrara F;Grehan K;Thompson CP;Temperton NJ
通讯作者：
Temperton NJ
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F