Quantitative analysis of internal components of the human crystalline lens during accommodation in adults.
Quantitative analysis of internal components of the human crystalline lens during accommodation in adults.
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DOI：
10.1038/s41598-021-86007-6
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发表时间：
2021-03-23
影响因子：
4.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Xiang Y;Fu T;Xu Q;Chen W;Chen Z;Guo J;Deng C;Manyande A;Wang P;Zhang H;Tian X;Wang J
定量分析成人适应过程中人体晶状体内部成分的变化。在0D、−3D和−6D调节状态下，对23名受试者的眼睛进行CASIA2光学相干断层扫描。采用内置软件测量前房深度（ACD）、晶状体前后曲率半径（ALRC和PLRC）。人工量化晶状体厚度（LT）、晶状体核厚度（NT）、前皮质厚度（ACT）、后皮质厚度（PCT）、前、后晶状体核曲率半径（ANRC和PNRC）、前、后晶状体核顶点（ANV和PNV）。在调节期间，ACD显著变浅，LT显著增加。对于晶状体的变化，ALRC平均降低了0.44 mm/D（与调节刺激相关），PLRC平均降低了0.09 mm/D。在不同的住宿州，ACT和PCT没有差异。对于透镜核响应，NT平均增加30 μm/D。ANRC和PNRC平均分别下降了212 μm/D和115 μm/D。在−3D调节刺激下，ANV平均向前移动0.07 mm，在−6D调节刺激下，ANV平均向前移动0.16 mm。然而，在PNV运动中，不同调节状态之间没有统计学上的显著差异。调节刺激下，晶状体厚度的变化主要是由晶状体核引起的，而不是皮层引起的。透镜状核的ANRC和PNRC均降低，ANRC变化最大。核的前表面向前移动，而核的后表面向后移动，但只是轻微的。
To quantitatively analyze changes in the inner components of the human crystalline lens during accommodation in adults. Eyes of 23 subjects were sequentially examined using CASIA2 Optical Coherence Tomography under 0D, − 3D and − 6D accommodation states. The anterior chamber depth (ACD), anterior and posterior crystalline lens radius of the curvature (ALRC and PLRC) were obtained using built-in software. The lens thickness (LT), lenticular nucleus thickness (NT), anterior cortex thickness (ACT), posterior cortex thickness (PCT), anterior and posterior lenticular nucleus radius of the curvature (ANRC and PNRC), anterior and posterior lenticular nucleus vertex (ANV and PNV) were quantified manually with the Image-pro plus software. During accommodation, the ACD became significantly shallower and LT significantly increased. For changes in the lens, the ALRC decreased by an average magnitude (related to accommodative stimuli) 0.44 mm/D, and PLRC decreased 0.09 mm/D. There was no difference for the ACT and PCT in different accommodation states. For lenticular nucleus response, NT increased on average by 30 μm/D. Both the ANRC and PNRC decreased on average by 212 μm/D and 115 μm/D respectively. The ANV moved forward on average by 0.07 mm under − 3D accommodative stimuli and 0.16 mm for − 6D. However, there was no statistically significant difference between different accommodation states in the PNV movement. Under accommodation stimulation, lens thickness changed mainly due to the lenticular nucleus, but not the cortex. For the lenticular nucleus, both the ANRC and PNRC decreased and ANRC changed the most. The anterior surface of the nucleus moved forward while the posterior surface of the nucleus moved backward but only slightly.
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影响因子：
3.4
作者：
Augusteyn, Robert C.
通讯作者：
Augusteyn, Robert C.
影响因子：
3.4
作者：
BROWN, N
通讯作者：
BROWN, N
影响因子：
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作者：
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通讯作者：
Tchah, Hungwon
影响因子：
1.8
作者：
Dubbelman, M;Van der Heijde, GL
通讯作者：
Van der Heijde, GL
影响因子：
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作者：
Gooi, Patrick;Ahmed, Ike K
通讯作者：
Ahmed, Ike K