GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior
GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior
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GPER 缺陷的大鼠表现出较低的血清皮质酮水平和增加的焦虑样行为
DOI：
10.1155/2020/8866187
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发表时间：
2020-08
影响因子：
3.1
通讯作者：
Rong Weifang
中科院分区：
文献类型：
--
作者：
Zheng Yi;Wu Meimei;Gao Ting;Meng Li;Ding Xiaowei;Meng Youqiang;Jiao Yingfu;Luo Ping;He Zhenquan;Sun Tao;Zhang Guohua;Shi Xueyin;Rong Weifang
充分的证据表明，雌激素对压力相关情绪障碍的发生有很强的影响，但潜在的机制仍然知之甚少。通过多种方法，我们证明了G蛋白偶联雌激素受体（GPER）广泛分布在下丘脑轴和与情绪控制有关的大脑结构中。基因消融大鼠GPER导致血清皮质酮水平显著降低，但ACTH释放增加，以应对急性约束应激，尤其是雌性。GPER - / -两种性别的大鼠都表现出增加的焦虑样行为和学习和记忆缺陷。此外，GPER缺乏导致单次延长应激（SPS）后焦虑样行为的加重。SPS引起WT大鼠血清皮质酮显著降低，而gper缺陷大鼠无此现象。这些结果强调了GPER在多个位点对下丘脑轴和情绪的调节中的重要作用。
Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain structures critically involved in mood control. Genetic ablation of GPER in the rat resulted in significantly lower basal serum corticosterone level but enhanced ACTH release in response to acute restraint stress, especially in the female. GPER−/− rats of either sex displayed increased anxiety-like behaviors and deficits in learning and memory. Additionally, GPER deficiency led to aggravation of anxiety-like behaviors following single-prolonged stress (SPS). SPS caused significant decreases in serum corticosterone in WT but not in GPER-deficient rats. The results highlight an important role of GPER at multiple sites in regulation of the HPA axis and mood.
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与压力有关的精神疾病的性别差异：神经生物学观点。
影响因子：
7.4
作者：
Bangasser, Debra A.;Valentino, Rita J.
通讯作者：
Valentino, Rita J.
影响因子：
3.7
作者：
Srikanth Yellayi;C. Teuscher;J. Woods;T. Welsh;K. Tung;M. Nakai;C. Rosenfeld;Dennis B. Lubann;P. Cooke
通讯作者：
Srikanth Yellayi;C. Teuscher;J. Woods;T. Welsh;K. Tung;M. Nakai;C. Rosenfeld;Dennis B. Lubann;P. Cooke
影响因子：
2.7
作者：
Hammerslag LR;Gulley JM
通讯作者：
Gulley JM
DOI：
10.1523/jneurosci.1298-14.2015
发表时间：
2015-02
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
E. Waters;L. Thompson;Parth Patel;Andreina D Gonzales;H. Z. Ye;E. Filardo;D. Clegg;Jolanta Gorecka-Jolanta-Gor
通讯作者：
E. Waters;L. Thompson;Parth Patel;Andreina D Gonzales;H. Z. Ye;E. Filardo;D. Clegg;Jolanta Gorecka-Jolanta-Gor
影响因子：
2.9
作者：
JOHNSTON, AL;FILE, SE
通讯作者：
FILE, SE