Excess body mass index loss predicts metabolic syndrome remission after gastric bypass.
Excess body mass index loss predicts metabolic syndrome remission after gastric bypass.
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DOI：
10.1186/1758-5996-6-1
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发表时间：
2014-01-02
影响因子：
4.8
通讯作者：
Monteiro MP
中科院分区：
文献类型：
--
作者：
Nora M;Guimarães M;Almeida R;Martins P;Gonçalves G;Santos M;Morais T;Freitas C;Monteiro MP
代谢综合征（MS）是一种与肥胖相关的疾病，可识别心血管风险增加的个体。胃转流术改善了几种MS组分，如葡萄糖、脂质代谢和高血压。本研究的目的是评估长肢胃旁路术对缓解与病态肥胖相关的MS标准的影响。前瞻性评价了符合MS“协调”标准的肥胖患者（n = 153）接受腹腔镜Roux-en-Y胃旁路术（LRYGB）和长胆胰支，术后36个月的体重、体重指数（BMI）、多余BMI丢失百分比（% EBMIL）、空腹血糖、血压和血脂。术前，患者的BMI为44.3 ± 0.5 kg/m2; 66%接受抗糖尿病治疗; 78.4%接受抗高血压治疗，44.3%接受抗血脂异常治疗。平均随访时间为2.4 ± 0.1年后，MS缓解率在6个月时为32.7%，在12个月时为69.7%，在24个月时为63.4%，在36个月时为59.2%;分别只有32.9%、43.4%和15.8%的患者仍在接受抗糖尿病、抗高血压和抗血脂异常治疗。%EBMIL和BMI是显示在手术后所有时间点预测MS缓解的最高准确度的参数。肥胖患者的长肢胃旁路术导致显著和持续的体重减轻，这预测MS的高缓解率，并允许大多数患者因几种代谢紊乱而停止药物治疗。
Metabolic syndrome (MS) is a condition associated with obesity that identifies individuals with increased cardiovascular risk. Gastric bypass improves several MS components, such as glucose, lipid metabolism and hypertension. The aim of this study was to evaluate the effect of long-limb gastric bypass on the remission of MS criteria associated with morbid obesity. Obese patients who met the “harmonized” criteria for MS (n = 153) that underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) with a long biliopancreatic limb were prospectively evaluated with regards to body weight, body mass index (BMI), percentage of excess BMI lost (% EBMIL), fasting glucose, blood pressure and lipid profile up to 36 months after surgery. Before surgery, patients had a BMI of 44.3 ± 0.5 kg/m2; 66% were under anti-diabetic treatment; 78.4% were under anti-hypertensive treatment and 44.3% were under anti-dyslipidemic treatment. After a mean follow-up time of 2.4 ± 0.1 years, MS remission rates were 32.7% at 6 months, 69.7% at 12 months, 63.4% at 24 months, and 59.2% at 36 months; when only 32.9%, 43.4% and 15.8% of patients were still under anti-diabetic, anti-hypertensive and anti-dyslipidemic treatment, respectively. The %EBMIL and BMI were the parameters that showed the highest accuracy to predict the MS remission at all-time points after the surgery. Long limb gastric bypass in obese patients results in significant and sustained weight loss which predicts a high remission rate of MS and allows the discontinuation of drug therapy for several metabolic disturbances in most patients.
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影响因子：
16.2
作者：
Isomaa, B;Almgren, P;Groop, L
通讯作者：
Groop, L
影响因子：
2.9
作者：
Antonio Gracia-Solanas, Jose;Elia, M.;Martinez, M.
通讯作者：
Martinez, M.
影响因子：
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作者：
Hu, G;Qiao, Q;Pyorala, K
通讯作者：
Pyorala, K
影响因子：
120.7
作者：
Fontaine, KR;Redden, DT;Allison, DB
通讯作者：
Allison, DB
影响因子：
8.9
作者：
Batsis JA;Romero-Corral A;Collazo-Clavell ML;Sarr MG;Somers VK;Lopez-Jimenez F
通讯作者：
Lopez-Jimenez F