Medial temporal lobe volume predicts elders' everyday memory.
Medial temporal lobe volume predicts elders' everyday memory.
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DOI：
10.1177/0956797612466676
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发表时间：
2013-07-01
影响因子：
8.2
通讯作者：
Sargent JQ
中科院分区：
文献类型：
--
作者：
Bailey HR;Zacks JM;Hambrick DZ;Zacks RT;Head D;Kurby CA;Sargent JQ
日常活动记忆缺陷是健康和痴呆老年人的常见抱怨。内侧颞叶和背外侧前额叶皮层都受到衰老和早期阿尔茨海默病的影响，并且已知会影响实验室记忆任务的表现。我们研究了这些结构的体积是否能预测日常记忆。认知健康的老年人和患有轻度阿尔茨海默氏型痴呆症的老年人观看了有关日常活动的电影，并完成了有关这些活动的记忆测试。使用结构MRI测量脑容量。内侧颞叶容量而不是前额叶容量强烈地预测了随后的记忆。日常记忆依赖于在感知过程中将活动分割成离散的事件，而内侧颞叶体积部分解释了记忆测试表现与事件分割任务表现之间的关系。本研究中使用的日常记忆测量包括情景和语义信息的检索以及工作记忆的更新。因此，目前的研究结果表明，在感知过程中，内侧颞叶支持决定后续记忆的事件表征的构建。
Deficits in memory for everyday activities are common complaints among healthy and demented older adults. The medial temporal lobes and dorsolateral prefrontal cortex are both affected by aging and early-stage Alzheimer's disease, and are known to influence performance on laboratory memory tasks. We investigated whether the volume of these structures predicts everyday memory. Cognitively healthy older adults and older adults with mild Alzheimer's-type dementia watched movies of everyday activities and completed memory tests on the activities. Structural MRI was used to measure brain volume. Medial temporal but not prefrontal volume strongly predicted subsequent memory. Everyday memory depends on segmenting activity into discrete events during perception, and medial temporal volume partially accounted for the relationship between performance on the memory tests and performance on an event-segmentation task. The everyday-memory measures used in this study involve retrieval of episodic and semantic information as well as working memory updating. Thus, the current findings suggest that during perception, the medial temporal lobes support the construction of event representations that determine subsequent memory.
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